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Volume 40  Issue 1,2025 2025年40卷第1 Issue
  • Editorial

    In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.

    Wei Zhou, Jing-Chen Zhang, De-Pei Liu

    Vol. 40, Issue 1, Pages: 1-2(2025) DOI: 10.24920/004471
      
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  • Perspective

    In the digital economy era, China's medical AI applications are advancing rapidly. The China National Health Development Research Center has established a value assessment framework for AI medical technologies, formulated the country's first technical guideline for clinical evaluation, and validated their practicality through scenario-based pilot studies. The paper also proposes introducing a "regulatory sandbox" model to test technical compliance in controlled environments, thereby balancing innovation incentives with risk governance.

    Mao You, Yue Xiao, Han Yao, Xue-Qing Tian, Li-Wei Shi, Ying-Peng Qiu

    Vol. 40, Issue 1, Pages: 3-8(2025) DOI: 10.24920/004473
    Abstract:Amid the global wave of digital economy, China's medical artificial intelligence applications are rapidly advancing through technological innovation and policy support, while facing multifaceted evaluation and regulatory challenges. The dynamic algorithm evolution undermines the consistency of assessment criteria, multimodal systems lack unified evaluation metrics, and conflicts persist between data sharing and privacy protection. To address these issues, the China National Health Development Research Center has established a value assessment framework for artificial intelligence medical technologies, formulated the country's first technical guideline for clinical evaluation, and validated their practicality through scenario-based pilot studies. Furthermore, this paper proposes introducing a "regulatory sandbox" model to test technical compliance in controlled environments, thereby balancing innovation incentives with risk governance.  
    Keywords:regulatory sandbox;medical artificial intelligence;health technology assessment   
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  • Review Article

    In the era of big data, biomedical data is growing rapidly, presenting challenges in data management. This article summarizes China's policies, data collection, platform construction, and applications in biomedical data, aiming to identify key issues and needs, enhance platform construction capacity, unleash data value, and leverage China's vast data advantages.

    Jing-Chen Zhang, Jing-Wen Sun, Xiao-Meng Liu, Jin-Yan Liu, Wei Luo, Sheng-Fa Zhang, Wei Zhou

    Vol. 40, Issue 1, Pages: 9-17(2025) DOI: 10.24920/004445
    Abstract:Biomedical data is surging due to technological innovations and integration of multidisciplinary data, posing challenges to data management. This article summarizes the policies, data collection efforts, platform construction, and applications of biomedical data in China, aiming to identify key issues and needs, enhance the capacity-building of platform construction, unleash the value of data, and leverage the advantages of China's vast amount of data.  
    Keywords:biomedical data;data management;database;data sharing;data resources;data platform   
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  • Review Article

    In the medical and health sectors, data space is emerging as an innovative model for data management and sharing. This study introduces its research progress in the field of data space, which provides solutions to solve the challenges of limited computing resources, data integration complexities, and the need for optimized algorithms. Technological innovation, sound regulations, and optimized management will help the development of the medical and health data space, enabling the secure and efficient utilization of data.

    Wan-Fei Hu, Si-Zhu Wu, Qing Qian

    Vol. 40, Issue 1, Pages: 18-28(2025) DOI: 10.24920/004466
    Abstract:Data space, as an innovative data management and sharing model, is emerging in the medical and health sectors. This study expounds on the conceptual connotation of data space and delineates its key technologies, including distributed data storage, standardization and interoperability of data sharing, data security and privacy protection, data analysis and mining, and data space assessment. By analyzing the real-world cases of data spaces within medicine and health, this study compares the similarities and differences across various dimensions such as purpose, architecture, data interoperability, and privacy protection. Meanwhile, data spaces in these fields are challenged by the limited computing resources, the complexities of data integration, and the need for optimized algorithms. Additionally, legal and ethical issues such as unclear data ownership, undefined usage rights, risks associated with privacy protection need to be addressed. The study notes organizational and management difficulties, calling for enhancements in governance framework, data sharing mechanisms, and value assessment systems. In the future, technological innovation, sound regulations, and optimized management will help the development of the medical and health data space. These developments will enable the secure and efficient utilization of data, propelling the medical industry into an era characterized by precision, intelligence, and personalization.  
    Keywords:data space;medical and health data;data sharing;privacy protection;data security   
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  • Review Article

    In the field of viral infectious diseases, this review explores the multifaceted nature of the diseases and summarizes relevant data across multiple levels. It traces the historical evolution of data collection, evaluates current limitations, and proposes strategies to surmount challenges, focusing on advanced computational techniques, AI-driven models, and enhanced data integration practices.

    Yun Ma, Lu-Yao Qin, Xiao Ding, Ai-Ping Wu

    Vol. 40, Issue 1, Pages: 29-44(2025) DOI: 10.24920/004461
    Abstract:Viral infectious diseases, characterized by their intricate nature and wide-ranging diversity, pose substantial challenges in the domain of data management. The vast volume of data generated by these diseases, spanning from the molecular mechanisms within cells to large-scale epidemiological patterns, has surpassed the capabilities of traditional analytical methods. In the era of artificial intelligence (AI) and big data, there is an urgent necessity for the optimization of these analytical methods to more effectively handle and utilize the information. Despite the rapid accumulation of data associated with viral infections, the lack of a comprehensive framework for integrating, selecting, and analyzing these datasets has left numerous researchers uncertain about which data to select, how to access it, and how to utilize it most effectively in their research.This review endeavors to fill these gaps by exploring the multifaceted nature of viral infectious diseases and summarizing relevant data across multiple levels, from the molecular details of pathogens to broad epidemiological trends. The scope extends from the micro-scale to the macro-scale, encompassing pathogens, hosts, and vectors. In addition to data summarization, this review thoroughly investigates various dataset sources. It also traces the historical evolution of data collection in the field of viral infectious diseases, highlighting the progress achieved over time. Simultaneously, it evaluates the current limitations that impede data utilization.Furthermore, we propose strategies to surmount these challenges, focusing on the development and application of advanced computational techniques, AI-driven models, and enhanced data integration practices. By providing a comprehensive synthesis of existing knowledge, this review is designed to guide future research and contribute to more informed approaches in the surveillance, prevention, and control of viral infectious diseases, particularly within the context of the expanding big-data landscape.  
    Keywords:viral infectious diseases;big data;data diversity and complexity;data standardization;artificial intelligence;data analysis   
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  • Review Article

    Biomedical big data, with its massive scale, multi-dimensionality, and heterogeneity, offers novel perspectives for disease research, elucidates biological principles, and simultaneously prompts changes in related research methodologies. Biomedical ontology, as a shared formal conceptual system, not only offers standardized terms for multi-source biomedical data but also provides a solid data foundation and framework for biomedical research. In this review, we summarize enrichment analysis and deep learning for biomedical ontology based on its structure and semantic annotation properties, highlighting how technological advancements are enabling the more comprehensive use of ontology information. Enrichment analysis represents an important application of ontology to elucidate the potential biological significance for a particular molecular list. Deep learning, on the other hand, represents an increasingly powerful analytical tool that can be more widely combined with ontology for analysis and prediction. With the continuous evolution of big data technologies, the integration of these technologies with biomedical ontologies is opening up exciting new possibilities for advancing biomedical research.

    Hong-Yu Fu, Yang-Yang Liu, Mei-Yi Zhang, Hai-Xiu Yang

    Vol. 40, Issue 1, Pages: 45-56(2025) DOI: 10.24920/004464
    Abstract:Biomedical big data, characterized by its massive scale, multi-dimensionality, and heterogeneity, offers novel perspectives for disease research, elucidates biological principles, and simultaneously prompts changes in related research methodologies. Biomedical ontology, as a shared formal conceptual system, not only offers standardized terms for multi-source biomedical data but also provides a solid data foundation and framework for biomedical research. In this review, we summarize enrichment analysis and deep learning for biomedical ontology based on its structure and semantic annotation properties, highlighting how technological advancements are enabling the more comprehensive use of ontology information. Enrichment analysis represents an important application of ontology to elucidate the potential biological significance for a particular molecular list. Deep learning, on the other hand, represents an increasingly powerful analytical tool that can be more widely combined with ontology for analysis and prediction. With the continuous evolution of big data technologies, the integration of these technologies with biomedical ontologies is opening up exciting new possibilities for advancing biomedical research.  
    Keywords:biomedical ontology;enrichment analysis;deep learning;ontology hierarchy;ontology annotation   
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