原始神经外胚层肿瘤作为长期存活的急性淋巴细胞白血病儿童的第二恶性肿瘤：病例报告

doi:10.24920/003653

Chinese Medical Sciences Journal ›› 2020, Vol. 35 ›› Issue (2): 186-190.doi: 10.24920/003653

原始神经外胚层肿瘤作为长期存活的急性淋巴细胞白血病儿童的第二恶性肿瘤：病例报告

张傲利^1,a²,陈晓娟^1a,李占奇^1b,竺晓凡^1,a^*()

^1a. 儿童血液病诊疗中心，中国医学科学院北京协和医学院血液病医院（中国医学科学院血液学研究所），实验血液学国家重点实验室，国家血液病临床医学研究中心，天津，300020 中国
^1b. 病理科；中国医学科学院北京协和医学院血液病医院（中国医学科学院血液学研究所），实验血液学国家重点实验室，国家血液病临床医学研究中心，天津，300020 中国
^2. 山西医科大学第二医院，血液科，太原，030001 中国

收稿日期:2019-08-15 接受日期:2019-08-30 出版日期:2020-06-30 发布日期:2020-06-16
通讯作者: 竺晓凡 E-mail:xfzhu1981@126.com

Primitive Neuroectodermal Tumor as the Second Malignant Neoplasm in a Long-Term Survivor Child of Acute Lymphoblastic Leukemia: A Case Report

Zhang Aoli^1,a²,Chen Xiaojuan^1a,Li Zhanqi^1b,Zhu Xiaofan^1,a^*()

^1a. Department of Pediatric Hematology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
^1b. Department of Pathology; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
^2. Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

Received:2019-08-15 Accepted:2019-08-30 Published:2020-06-30 Online:2020-06-16
Contact: Zhu Xiaofan E-mail:xfzhu1981@126.com

摘要/Abstract

摘要：

急性淋巴细胞白血病是一种常见的儿童肿瘤。第二恶性肿瘤在长期存活的急性淋巴细胞白血病患儿中极少见,且预后差。我们报告一位初诊并接受无放射治疗急性淋巴细胞白血病的10岁女孩,5年后诊断为原始神经外胚层肿瘤（primitive neuroectodermal tumor,PNET)。在急性淋巴细胞白血病存活的儿童中,原始神经外胚层肿瘤是一种非常罕见的继发恶性肿瘤,且容易被误诊,发病机制尚不清楚,预后不良。因此,长期随访存活的急性淋巴细胞白血病儿童是非常必要的。

关键词: 原始神经外胚层肿瘤, 第二恶性肿瘤, 儿童, 急性淋巴细胞白血病

Abstract:

Acute lymphoblastic leukemia (ALL) is a common pediatric cancer. The second malignant neoplasms (SMNs) in long-term survivors of pediatric ALL are relatively rare. Herein we report a 10-year-old girl who was diagnosed as primitive neuroectodermal tumor (PNET) 5 years after the initial diagnosis of ALL with radiotherapy-free treatment. PNET is an exceedingly rare neoplasm in SMNs of survivors of childhood ALL. It is predisposed to be misdiagnosed and the pathogenesis is unclear. The outcome is poor. Long-term follow-up is necessary for the survival children of ALL.

Key words: primitive neuroectodermal tumor, second malignant neoplasms, childhood, acute lymphoblastic leukemia

Zhang Aoli,Chen Xiaojuan,Li Zhanqi,Zhu Xiaofan. Primitive Neuroectodermal Tumor as the Second Malignant Neoplasm in a Long-Term Survivor Child of Acute Lymphoblastic Leukemia: A Case Report[J].Chinese Medical Sciences Journal, 2020, 35(2): 186-190.

图/表 3

参考文献 15.

1.	Ward E, DeSantis C, Robbins A, et al. Childhood and adolescent cancer statistics 2014. CA Cancer J Clin 2014; 64(2):83-103. doi: 10.3322/caac.21219. doi: 10.3322/caac.21219 pmid: 24488779
2.	Hunger SP, Lu X, Devidas M , et al. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group. J Clin Oncol 2012; 30(14):1663-9. doi: 10.1200/JCO.2011.37.8018. doi: 10.1200/JCO.2011.37.8018
3.	Schmiegelow K, Levinsen MF, Attarbaschi A , et al. Second malignant neoplasms after treatment of childhood acute lymphoblastic leukemia. J Clin Oncol 2013; 31(19):2469-76. doi: 10.1200/JCO.2012.47.0500. doi: 10.1200/JCO.2012.47.0500
4.	Loning L, Zimmermann M, Reiter A , et al. Secondary neoplasms subsequent to Berlin-Frankfurt-Munster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy. Blood 2000; 95(9):2770-5. pmid: 10779419
5.	Antillon F, Kaste SC, Jenkins JJ , et al. Primitive neuroectodermal tumor of bone as a second malignant neoplasm in a child previously treated for acute lymphoblastic leukemia. J Pediatr Hematol Oncol 1997; 19(5):473-6. doi: 10.1097/00043426-199709000-00014 pmid: 9329474
6.	Suarez CR, Bertolone SJ, Raj AB , et al. Second malignant neoplasms in childhood acute lymphoblastic leukemia: primitive neuroectodermal tumor of the chest wall with germline p53 mutation as a second malignant neoplasm. Am J Hematol 2004; 76(1):52-6. doi: 10.1002/ajh.20012. doi: 10.1002/ajh.20012 pmid: 15114597
7.	Yoshida Y, Toma Y, Arai M , et al. Primitive neuroectodermal tumor arising 8 years after chemotherapy and radiotherapy for acute lymphoblastic leukemia: case report. No Shinkei Geka 2005; 33(7):717-22. Japanese. pmid: 16001813
8.	Sobowale OA, McCabe M, Pal P, et al. Radiotherapy-induced supratentorial primitive neuroectodermal tumour in a 17-year-old female: a case report and review of the literature. Acta Neurochir (Wien) 2011; 153(2):413-7. doi: 10.1007/s00701-010-0890-4. doi: 10.1007/s00701-010-0890-4
9.	Cui L, Li ZG, Chai YH , et al. Outcome of children with newly diagnosed acute lymphoblastic leukemia treated with CCLG-ALL 2008: The first nation-wide prospective multicenter study in China. Am J Hematol 2018; 93(7):913-20. doi: 10.1002/ajh.25124. doi: 10.1002/ajh.25124 pmid: 29675840
10.	Chen XJ, Zou Y, Liu XM , et al. Long-term clinical effect of the CCLG-ALL2008 regimen in treatment of childhood acute lymphoblastic leukemia with different molecular biological features. Chin J contempor pediatr 2019; 21(9):890-3. Chinese. doi: 10.7499/j.issn.1008-8830.2019.09.009.
11.	Carvajal R, Meyers P. Ewing’s sarcoma and primitive neuroectodermal family of tumors. Hematol Oncol Clin North Am 2005; 19(3):501-25, vi-vii. doi: 10.1016/j.hoc.2005.03.004. doi: 10.1016/j.hoc.2005.03.004 pmid: 15939194
12.	Yi X, Liu W, Zhang Y , et al. Radiological features of primitive neuroectodermal tumors in intra-abdominal and retroperitoneal regions: A series of 18 cases. Plos One 2017; 12(3):e0173536. doi: 10.1371/journal.pone.0173536. doi: 10.1371/journal.pone.0173536 pmid: 28319177
13.	Schmiegelow K, Al-Modhwahi I, Andersen MK , et al. Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. Blood 2009; 113(24):6077-84. doi: 10.1200/jco.2012.47.0500. doi: 10.1182/blood-2008-11-187880 pmid: 19224761
14.	Ng A, Taylor GM, Eden OB . Treatment-related leukaemia: a clinical and scientific challenge. Cancer Treat Rev 2000; 26(5):377-91. doi: 10.1053/ctrv.2000.0186. doi: 10.1053/ctrv.2000.0186 pmid: 11006138
15.	Amirjamshidi A, Abbassioun K . Radiation-induced tumors of the central nervous system occurring in childhood and adolescence Four unusual lesions in three patients and a review of the literature. Childs Nerv Syst 2000; 16(7):390-7. doi: 10.1007/s003819900125. doi: 10.1007/s003819900125 pmid: 10958546

Studies*	Age (years)	Sex	Family history	Radiation therapy	PNET diagnosis^#(years)	Gene mutation	Outcome
Antillon et al. 1997^[5]	7	Female	Breast cancer in a maternal great-aunt	No	10	P53 (exon 5-9)	Relapse
Suarez et al. 2004^[6]	3	Male	Negative	Not mentioned	5	P53 (exon 7)	Off therapy and disease-free for 2 years
Yoshida et al. 2005^[7]	7	Male	Mother died of breast cancer; maternal grandfather died of gastric cancer; kindred marriages	Cranial radiotherapy, 22Gy	8	Not mentioned	No evidence of recurrent tumor for 4 months
Sobowale et al. 2011^[8]	0.7	Female	Not mentioned	Cranial radiotherapy, 24 Gy	16	Not mentioned	Death

[1]	张扬, 卞爱玲, 梁安怡, 莫菲, 程钢炜. 二氧化碳激光辅助深层巩膜切除术联合小梁切除术治疗1例继发于Weill-Marchesani综合征的难治性儿童青光眼[J]. Chinese Medical Sciences Journal, 2022, 37(2): 159-163.
[2]	杨广娥, 赵忠礼, 杨阳, 林丽, 宋丛磊, 汪晓翠, 杨斌. ATP1A3基因突变致儿童交替性偏瘫：2例病例报道[J]. Chinese Medical Sciences Journal, 2021, 36(2): 150-157.
[3]	具杨花, 乔红梅, 张影, 李亚男. 3例病毒相关性儿童横纹肌溶解症的临床分析与文献复习[J]. Chinese Medical Sciences Journal, 2020, 35(4): 383-386.

优先出版

当期目次

过刊浏览

虚拟专题

作者中心

评阅者中心

原始神经外胚层肿瘤作为长期存活的急性淋巴细胞白血病儿童的第二恶性肿瘤：病例报告

Primitive Neuroectodermal Tumor as the Second Malignant Neoplasm in a Long-Term Survivor Child of Acute Lymphoblastic Leukemia: A Case Report

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 3

参考文献 15.

相关文章 3

Metrics

推荐阅读 10