Chinese Medical Sciences Journal ›› 2020, Vol. 35 ›› Issue (2): 186-190.doi: 10.24920/003653

• 病例报告 • 上一篇    下一篇

原始神经外胚层肿瘤作为长期存活的急性淋巴细胞白血病儿童的第二恶性肿瘤:病例报告

张傲利1,a2,陈晓娟1a,李占奇1b,竺晓凡1,a*()   

  1. 1a. 儿童血液病诊疗中心,中国医学科学院北京协和医学院血液病医院(中国医学科学院血液学研究所),实验血液学国家重点实验室,国家血液病临床医学研究中心,天津,300020 中国
    1b. 病理科;中国医学科学院北京协和医学院血液病医院(中国医学科学院血液学研究所),实验血液学国家重点实验室,国家血液病临床医学研究中心,天津,300020 中国
    2. 山西医科大学第二医院,血液科,太原,030001 中国
  • 收稿日期:2019-08-15 接受日期:2019-08-30 出版日期:2020-06-30 发布日期:2020-06-14
  • 通讯作者: 竺晓凡 E-mail:xfzhu1981@126.com

Primitive Neuroectodermal Tumor as the Second Malignant Neoplasm in a Long-Term Survivor Child of Acute Lymphoblastic Leukemia: A Case Report

Zhang Aoli1,a2,Chen Xiaojuan1a,Li Zhanqi1b,Zhu Xiaofan1,a*()   

  1. 1a. Department of Pediatric Hematology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
    1b. Department of Pathology; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
    2. Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2019-08-15 Accepted:2019-08-30 Published:2020-06-30 Online:2020-06-14
  • Contact: Zhu Xiaofan E-mail:xfzhu1981@126.com

摘要:

急性淋巴细胞白血病是一种常见的儿童肿瘤。第二恶性肿瘤在长期存活的急性淋巴细胞白血病患儿中极少见,且预后差。我们报告一位初诊并接受无放射治疗急性淋巴细胞白血病的10岁女孩,5年后诊断为原始神经外胚层肿瘤(primitive neuroectodermal tumor,PNET)。在急性淋巴细胞白血病存活的儿童中,原始神经外胚层肿瘤是一种非常罕见的继发恶性肿瘤,且容易被误诊,发病机制尚不清楚,预后不良。因此,长期随访存活的急性淋巴细胞白血病儿童是非常必要的。

关键词: 原始神经外胚层肿瘤, 第二恶性肿瘤, 儿童, 急性淋巴细胞白血病

Abstract:

Acute lymphoblastic leukemia (ALL) is a common pediatric cancer. The second malignant neoplasms (SMNs) in long-term survivors of pediatric ALL are relatively rare. Herein we report a 10-year-old girl who was diagnosed as primitive neuroectodermal tumor (PNET) 5 years after the initial diagnosis of ALL with radiotherapy-free treatment. PNET is an exceedingly rare neoplasm in SMNs of survivors of childhood ALL. It is predisposed to be misdiagnosed and the pathogenesis is unclear. The outcome is poor. Long-term follow-up is necessary for the survival children of ALL.

Key words: primitive neuroectodermal tumor, second malignant neoplasms, childhood, acute lymphoblastic leukemia

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