Chinese Medical Sciences Journal ›› 2021, Vol. 36 ›› Issue (4): 316-322.doi: 10.24920/003859

• 综述 • 上一篇    下一篇

视神经脊髓炎谱系疾病合并疼痛抑郁共病综述

张雪1,徐雁2,裴丽坚1,*()   

  1. 1麻醉科,中国医学科学院北京协和医院,北京,100730,中国
    2神经内科,中国医学科学院北京协和医院,北京,100730,中国
  • 收稿日期:2020-11-30 出版日期:2021-12-31 发布日期:2022-01-06
  • 通讯作者: 裴丽坚 E-mail:hazelbeijing@vip.163.com

Review of Neuromyelitis Optica Spectrum Disorder with Pain-Depression Comorbidity

Xue Zhang1,Yan Xu2,Lijian Pei1,*()   

  1. 1Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    2Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  • Received:2020-11-30 Published:2021-12-31 Online:2022-01-06
  • Contact: Lijian Pei E-mail:hazelbeijing@vip.163.com

摘要:

视神经脊髓炎谱系疾病是一种中枢神经系统炎性疾病,主要累及视神经及脊髓,在亚洲人群中发病率显著高于世界其他地区。80%以上视神经脊髓炎谱系疾病患者合并疼痛症状,其中痛性痉挛及神经病理性疼痛最具特点。抑郁常与疼痛共存,严重影响患者生活质量。近年来,很多研究发现疼痛与抑郁在机制上存在重叠,然而两者之间的联系仍不明确。本文对视神经脊髓炎谱系疾病患者合并疼痛抑郁共病的流行病学特征、发病机制及诊断治疗进行综述。

关键词: 视神经脊髓炎谱系疾病, 疼痛, 抑郁, 共病

Abstract:

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disorder of the central nervous system predominantly targeting optic nerves and the spinal cord. The prevalence of the disease is much higher in Asia than in other parts of the world. Pain can be detected in more than 80% of NMOSD patients, with evoked pain mostly being caused by painful tonic muscle spasms and neuropathic pain as the most characteristic types. Depression is often comorbid with pain, and their comorbidity can severely influence quality of life. In recent years, studies have found considerable overlaps between the mechanisms of pain and depression; however, their association remains unclear. This article reviews the epidemiology, mechanism, evaluation and treatment of pain-depression comorbidity in NMOSD patients.

Key words: neuromyelitis optica spectrum disorder, pain, depression, comorbidity

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