Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (1): 73-78.doi: 10.24920/003990

• 综述 • 上一篇    下一篇

角蛋白在胃肠道肿瘤中的作用和研究进展

欧阳思文1,2,康维明2,*()   

  1. 1中国医学科学院北京协和医学院,北京100730,中国
    2中国医学科学院北京协和医院基本外科,北京100010,中国
  • 收稿日期:2021-08-30 接受日期:2021-12-23 出版日期:2022-03-31 发布日期:2022-03-10
  • 通讯作者: 康维明 E-mail:pumchkangweiming@126.com

Research Advances in the Role of Keratins in Gastrointestinal Cancer

Siwen Ouyang1,2,Weiming Kang2,*()   

  1. 1Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100010, China
  • Received:2021-08-30 Accepted:2021-12-23 Published:2022-03-31 Online:2022-03-10
  • Contact: Weiming Kang E-mail:pumchkangweiming@126.com

摘要:

胃肠道肿瘤的发病率和死亡率居高不下。尽管诊断和治疗技术在不断改进,胃肠道肿瘤的早期诊断、中期和晚期治疗、药物耐受性以及癌症复发和转移等问题仍构成巨大挑战。在本篇综述中,我们总结了角蛋白在胃肠道肿瘤中的作用和研究进展,希望它们能成为预测、诊断或治疗胃肠道肿瘤的有效生物标志物。

关键词: 角蛋白, 胃肠道肿瘤, 诊断意义, 机制

Abstract:

The incidence and mortality rates of gastrointestinal (GI) cancer remain high. Despite constant improvements in diagnostic and therapeutic techniques, the early diagnosis, mid- and late-stage treatment, drug tolerance, and cancer recurrence and metastasis in GI cancer remain challenging. In this review article we summarize the recent research advance in the roles of keratins in GI cancer, with the hope that they will become efficient biomarkers for the prediction, diagnosis, or treatment of these malignancies.

Key words: Keratin, gastrointestinal cancer, diagnostic significance, mechanism

基金资助: 吴阶平医学基金会(320.6750.19020)

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