ANCA相关血管炎继发肾淀粉样变性：1例病例报告

doi:10.24920/003999

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摘要： 摘要：临床上继发于抗中性粒细胞胞浆抗体（anti-neutrophil cytoplasmic antibody，ANCA）相关血管炎的淀粉样蛋白A（amyloid A，AA）型淀粉样变性病例十分罕见。我们收治了1例77岁的ANCA相关血管炎女性患者。经活检取肾组织标本，Masson三色染色提示寡免疫复合物型新月体性肾小球炎；在电子显微镜下观察可见肾小球系膜区淀粉样物质沉积；免疫荧光染色显示λ轻链和κ轻链染色阴性。骨髓活组织检查未见浆细胞异常增生。最终，我们做出ANCA相关血管炎多血管炎继发AA型淀粉样变的诊断。

Abstract: Abstract: Renal amyloidosis secondary to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is extremely rare. Here, we reported a 77-year-old woman with ANCA-associated vasculitis. Renal biopsy with Masson trichrome staining showed pauci-immune crescentic glomerulonephritis, and electron microscopy showed amyloid deposition in the mesangial area. Immunofluorescence revealed kappa light chain and lambda light chain were negative. Bone marrow biopsy revealed no clonal plasma cell. Finally, she was diagnosed as ANCA-associated vasculitis with secondary renal amyloid A amyloidosis.

Key words: anti-neutrophil cytoplasmic antibody-associated vasculitis, amyloidosis

Xin He, Jianping Ning, Hui Xu, Gong Xiao, Huixiang Yang, Weiyuan Wang, Xiaoying Wu, Hongling Yin, Xiaozhao Li. Renal amyloidosis secondary to ANCA-associated vasculitis: a case report[J/OL].Chinese Medical Sciences Journal, .DOI:10.24920/003999.[Epub ahead of print].

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ANCA相关血管炎继发肾淀粉样变性：1例病例报告

Renal amyloidosis secondary to ANCA-associated vasculitis: a case report

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