Chinese Medical Sciences Journaldoi: 10.24920/004065

• 论著 •    下一篇

发展中国家空气污染与2型糖尿病的系统评价和Meta分析

陈紫晗#1,赵洲#1,2,邓垂文3,李乃适1*   

  1. 1 中国医学科学院北京协和医院内分泌科,北京 100730
    2 北京航天总医院 干部医疗科,北京 100076
    3 中国医学科学院北京协和医院风湿免疫科,北京 100730 #共同第一作者。  *通讯作者。
  • 收稿日期:2022-01-20 修回日期:2022-05-22 接受日期:2022-07-01 出版日期:2022-06-20 发布日期:2022-06-20

Association between Air Pollution and Type 2 Diabetes Mellitus in Developing Countries: A Systematic Review and Meta-Analysis

Zihan Chen#1, Zhou Zhao#1,2, Chuiwen Deng3, Naishi Li1*   

  1. 1 Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Hospital, Beijing 100730, China.
    2 Beijing Aerospace General Hospital, Cadre Medical Department, Beijing 100076, China.
    3 Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, the Ministry of Education Key Laboratory, Beijing 100730, China.

    # Co-first authors.

    * Corresponding author.

  • Received:2022-01-20 Revised:2022-05-22 Accepted:2022-07-01 Published:2022-06-20 Online:2022-06-20

摘要: 目的 近年来,研究指出空气污染是2型糖尿病的危险因素。本文采用Meta分析方法评价发展中国家空气污染与2型糖尿病之间的联系。
方法 计算机检索PubMed、EMABASE和Web of Science数据库,截止到2022年03月31日,内容是关于发展中国家空气污染与2型糖尿病患病率或发病率之间关系的研究,使用比值比(OR值)来评估疗效,对纳入的研究进行Meta分析。
结果 共纳入在发展中国家进行的8项横断面研究和8项队列研究,对8项PM2.5相关的研究进行了Meta分析的荟萃分析,结果显示,暴露于PM2.5使得2型糖尿病患病率增加,相关性1.12 (95% CI 1.07, 1.17)。由于纳入文献数量有限,未能定量评价空气污染与2型糖尿病发病率之间的相关性。
结论 在发展中国家,鉴于暴露于PM2.5会导致2型糖尿病患病率增加,糖尿病易感人群应该注意减少空气污染暴露。

关键词: 空气污染, PM2.5, 2型糖尿病

Abstract: Objective In recent years, many studies have reported that air pollution is a risk factor for type 2 diabetes mellitus (T2DM). The aim of this systematic review and meta-analysis is to summarize the evidence about the association between exposure to air pollution and T2DM in developing countries.
Methods The databases, including PubMed, EMBASE and Web of Science, were systematically searched for studies published up to 31 March 2022. Studies about the association between air pollution and T2DM prevalence or incidence in developing countries were included. The odds ratio (OR) was used as effect estimate. We synthesized the included studies in meta-analyses.
Results We included 8 cross-sectional studies and 8 cohort studies, all conducted in developing countries. Meta-analyses of 8 studies on PM2.5 (particulate matter ≤ 2.5 μm in diameter) showed that the overall effect estimate of T2DM prevalence upon exposure to PM2.5 was 1.12 (95% CI: 1.07, 1.17). The association between air pollutants and T2DM incidence was not estimated due to the limited relevant studies.
Conclusions The exposure to PM2.5 would be positively associated with an increased prevalence of T2DM in developing countries. Some effective measures should be taken to reduce air pollution exposure in people who are vulnerable to diabetes.

Key words: Air pollutants, PM2.5, Type 2 diabetes mellitus

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