Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (3): 218-227.doi: 10.24920/004065

• 科学数据共享与重用: 论著 • 上一篇    下一篇



  1. 1中国医学科学院北京协和医学院 北京协和医院 内分泌科,北京 100730
    2北京航天总医院 干部医疗科,北京 100076
    3中国医学科学院北京协和医学院 北京协和医院 风湿免疫科,北京 100730
  • 收稿日期:2022-01-20 接受日期:2022-05-31 出版日期:2022-09-30 发布日期:2022-06-20
  • 通讯作者: 李乃适

Association between Air Pollution and Type 2 Diabetes Mellitus in Developing Countries: A Systematic Review and Meta-Analysis

Zihan Chen1,Zhou Zhao1,2,Chuiwen Deng3,Naishi Li1,*()   

  1. 1Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China
    2Cadre Medical Department, Beijing Aerospace General Hospital, Beijing 100076, China
    3Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, the Ministry of Education Key Laboratory, Beijing 100730, China
  • Received:2022-01-20 Accepted:2022-05-31 Published:2022-09-30 Online:2022-06-20
  • Contact: Naishi Li


目的 研究指出空气污染是2型糖尿病的危险因素。本文采用Meta分析方法评价发展中国家空气污染与2型糖尿病之间的联系。
方法 使用计算机检索PubMed、EMBASE和Web of Science数据库内截至2022年03月31日发表的发展中国家空气污染与2型糖尿病患病率或发病率之间关系的研究论文。使用比值比(OR)来评估疗效,对纳入的研究进行Meta分析。
结果 共纳入在发展中国家进行的8项横断面研究和8项队列研究。对8项PM2.5相关的研究进行的Meta分析显示,暴露于PM2.5使2型糖尿病患病率增加,相关性为1.12(95% CI 1.07,1.17)(P<0.001)。由于纳入文献数量有限,未能定量评价空气污染与2型糖尿病发病率之间的相关性。
结论 在发展中国家,暴露于PM2.5会导致2型糖尿病患病率增加。糖尿病易感人群应该注意减少空气污染暴露。

关键词: 空气污染, PM2.5, 2型糖尿病


Objective In recent years, many studies have reported that air pollution is a risk factor for type 2 diabetes mellitus (T2DM). The aim of this systematic review and meta-analysis is to summarize the evidence about the association between exposure to air pollution and T2DM in developing countries.
Methods The databases, including PubMed, EMBASE and Web of Science, were systematically searched for studies published up to 31 March 2022. Studies about the association between air pollution and T2DM prevalence or incidence in developing countries were included. The odds ratio (OR) was used as effect estimate. We synthesized the included studies in the meta-analysis.
Results We included 8 cross-sectional studies and 8 cohort studies, all conducted in developing countries. Meta-analysis of 8 studies on PM2.5 (particulate matter ≤ 2.5 μm in diameter) showed that T2DM prevalence was significantly associated with PM2.5 exposure (OR=1.12; 95% CI: 1.07, 1.17; P<0.001). The association between air pollutants and T2DM incidence was not estimated due to the limited relevant studies.
Conclusions The exposure to PM2.5 would be positively associated with an increased prevalence of T2DM in developing countries. Some effective measures should be taken to reduce air pollutant exposure in people who are vulnerable to diabetes.

Key words: Air pollutants, PM2.5, type 2 diabetes mellitus

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