三维伪连续动脉自旋标记序列的可重复性：不同功能状态的健康成人在不同标记时间的脑容积灌注成像

doi:10.24920/11803

摘要/Abstract

摘要： 目的评估三维螺旋自旋回波伪连续动脉自旋标记序列在静息或右手对指运动状态下,在不同标记时间测量脑血流量的可重复性。方法连续一周在同一时间采用脑部三维伪连续动脉自旋标记及三维T1快速毁损梯度回波序列采集8名健康受试者的脑部图像。分别在静息及右手对指运动状态下施加1.5 s及2.0 s标记时间采集动脉自旋标记数据,计算脑血流量图,并自动提取脑灰质及白质脑血流量。采用组内相关系数及Bland-Altman图评估此技术的可重复性。结果静息状态下,标记时间1.5 s提取的脑血流灌注图显示灰质（0.84）及白质（0.92）的组内相关系数均低于标记时间2.0 s的数值（灰质,0.88;白质,0.94）。标记时间1.5 s时,右手对指运动状态下的灰质组内相关系数（0.88）大于静息状态下的灰质组内相关系数。第一次扫描时,标记时间1.5 s和2.0 s的灰质及白质的组内相关系数分别为0.71和0.78,第二次扫描时,两者的数值分别为0.83和0.79。结论在静息或控制状态下和在不同标记时间,三维伪连续动脉自旋标记序列测量健康人全脑血流量具有可重复性。

关键词: 伪连续动脉自旋标记, 磁共振成像, 组内相关系数, 可重复性

Abstract: Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling (3D pc-ASL) in measuring cerebral blood flow (CBF) with different post-labeling delay time (PLD) in the resting state and the right finger taping state.Methods 3D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR) sequence were applied to eight healthy subjects twice at the same time each day for one week interval. ASL data acquisition was performed with post-labeling delay time (PLD) 1.5 seconds and 2.0 seconds in the resting state and the right finger taping state respectively. CBF mapping was calculated and CBF value of both the gray matter (GM) and white matter (WM) was automatically extracted. The reliability was evaluated using the intraclass correlation coefficient (ICC) and Bland and Altman plot.Results ICC of the GM (0.84) and WM (0.92) was lower at PLD 1.5 seconds than that (GM, 0.88; WM, 0.94) at PLD 2.0 seconds in the resting state, and ICC of GM (0.88) was higher in the right finger taping state than that in the resting state at PLD 1.5 seconds. ICC of the GM and WM was 0.71 and 0.78 for PLD 1.5 seconds and PLD 2.0 seconds in the resting state at the first scan, and ICC of the GM and WM was 0.83 and 0.79 at the second scan, respectively.Conclusion This work demonstrated that 3D pc-ASL might be a reliable imaging technique to measure CBF over the whole brain at different PLD in the resting state or controlled state.

Key words: pseudo-continuous arterial spin labeling, magnetic resonance imaging, intraclass correlation coefficient, reliability

Liu Mengqi, Chen Zhiye, Ma Lin. Reliability of Three Dimentional Pseudo-continuous Arterial Spin Labeling: A Volumetric Cerebral Perfusion Imaging with Different Post-labeling Time and Functional State in Health Adults[J].Chinese Medical Sciences Journal, 2018, 33(1): 38-44.

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Table 1

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Table 2

Figure 3.

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Acquisition parameters	CBF value [ml/(min·100 ml)]		ICC (95%CI)
Acquisition parameters	First scan	Second scan	ICC (95%CI)
rs1.5
GM	47.03±7.46	50.25±5.94	0.84 (0.05-0.97)
WM	43.09±5.53	44.19±5.83	0.92 (0.67-0.98)
rs2.0
GM	50.41±5.36	51.13±3.97	0.88 (0.54-0.97)
WM	45.30±4.60	46.25±4.50	0.94 (0.69-0.99)
ft1.5
GM	48.78±6.79	47.55±8.20	0.88 (0.54-0.97)
WM	42.18±4.93	42.66±5.22	0.92 (0.66-0.98)

Region	CBF value (ml/min·100 ml)		ICC (95%CI)
Region	rs1.5	rs2.0	ICC (95%CI)
First scan
GM	47.03±7.46	50.41±5.36	0.71 (0.08-0.94)
WM	43.09±5.53	45.30±4.60	0.78 (0.20-0.95)
Second scan
GM	50.25±5.94	51.13±3.97	0.83 (0.39-0.96)
WM	44.19±5.83	46.25±4.50	0.79 (0.26-0.96)

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