病理性瘢痕血供及组织缺氧的研究进展

doi:10.24920/J1001-9294.2017.014

摘要/Abstract

摘要：

血供在病理性瘢痕的形成中起到重要作用,近年来备受关注。然而关于血管分布、血管结构、血流量的相关研究结论争议颇多。此外,缺氧微环境在病理性瘢痕组织的血管化过程中起到重要作用,影响相关代谢指标及细胞因子的表达。血供与组织缺氧之间有密切关系,但仍不甚明了。本文就病理性瘢痕血供及组织缺氧的研究进展进行综述,阐述病理性瘢痕的血供特点及与组织缺氧的联系,并对未来研究方向进行展望。

关键词: 病理性瘢痕, 增生性瘢痕, 瘢痕疙瘩, 血供, 缺氧

Abstract:

Blood supply is believed to be an important aspect in the development of pathological scars. However, there are controversies about vascular distribution, vascular structure and blood flow in pathological scars. Additionally, hypoxic microenvironment plays an important role in the vascularization of pathological scar tissues, and hypoxic conditions can be reflected by metabolic indexes and some cytokines. Furthermore, the correlation between blood supply and tissue hypoxia is controversial. The aim of this article is to review the literature on the characteristics of blood supply and tissue hypoxia in pathological scars, from which we can see pathological scars have unique characteristics of blood supply that are closely associated with tissue hypoxia. Moreover, development in the treatment of pathological scars is herein reviewed.

Key words: pathological scar, hypertrophic scar, keloid, blood flow, hypoxia

Li Zifei, Liu Qingliang, Wang Xiaojun, Luan Jie. The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars[J].Chinese Medical Sciences Journal, 2017, 32(2): 113-118.

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