Chinese Medical Sciences Journal ›› 2013, Vol. 28 ›› Issue (3): 129-134.doi: 10.1016/S1001-9294(13)60037-1

• 论著 •    下一篇

Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition

Yi Bao*,Ling-juan Ruan, Juan-fen Mo   

  1. Key Laboratory, Jiaxing Second Hospital, Jiaxing University, Jiaxing, Zhejiang 314000, China
  • 收稿日期:2013-02-20 出版日期:2013-09-30 发布日期:2013-09-30
  • 通讯作者: *Corresponding author Tel: 86-573-82073185, Fax: 86-573-82082936, E-mail: ybao2011@gmail.com

Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition

Yi Bao*,Ling-juan Ruan, Juan-fen Mo   

  1. Key Laboratory, Jiaxing Second Hospital, Jiaxing University, Jiaxing, Zhejiang 314000, China
  • Received:2013-02-20 Published:2013-09-30 Online:2013-09-30
  • Contact: *Corresponding author Tel: 86-573-82073185, Fax: 86-573-82082936, E-mail: ybao2011@gmail.com

摘要: Methods The transcripts of TRPS-1 and its role in survival in breast cancer were analyzed using published microarray data sets—Netherlands Cancer Institute (NKI) cohort and Wang cohort.Results TRPS-1 expression was lower in basal-like breast cancer. The mRNA levels of TRPS-1 negatively correlated with Slug (Pearson correlation coefficient=-0.1366, P=0.0189 in NKI data set and Pearson correlation coefficient=-0.1571, P=0.0078 in Wang data set), FOXC1 (Pearson correlation coefficient=-0.1211, P=0.0376 in NKI data set and Pearson correlation coefficient=-0.1709, P=0.0037 in Wang data set), and CXCL1 (Pearson correlation coefficient=-0.1197, P=0.0399 in NKI data set and Pearson correlation coefficient=-0.3436, P<0.0001 in Wang data set), but positively correlated with BRCA1 (Pearson correlation coefficient=0.1728, P=0.0029 in NKI data set and Pearson correlation coefficient=0.1805, P=0.0022 in Wang data set). Low TRPS-1 expression associated with poor overall survival (hazard ratio 1.79, 95% CI of ratio 0.9894 to 3.238, P=0.054) and relapse-free survival (hazard ratio 1.913, 95% CI of ratio 1.159 to 3.156, P<0.05). The low TRPS-1 mRNA levels predicted poor outcome in breast cancer patients by the 70-gene signature.ConclusionThe strong expression of TRPS-1 may serve as a good prognostic marker in breast cancer.

关键词: ductal epithelial cells, trichorhinophalangeal syndrome 1 gene, Slug, epithelial mesenchymal transition, breast cancer

Abstract: Methods The transcripts of TRPS-1 and its role in survival in breast cancer were analyzed using published microarray data sets—Netherlands Cancer Institute (NKI) cohort and Wang cohort.Results TRPS-1 expression was lower in basal-like breast cancer. The mRNA levels of TRPS-1 negatively correlated with Slug (Pearson correlation coefficient=-0.1366, P=0.0189 in NKI data set and Pearson correlation coefficient=-0.1571, P=0.0078 in Wang data set), FOXC1 (Pearson correlation coefficient=-0.1211, P=0.0376 in NKI data set and Pearson correlation coefficient=-0.1709, P=0.0037 in Wang data set), and CXCL1 (Pearson correlation coefficient=-0.1197, P=0.0399 in NKI data set and Pearson correlation coefficient=-0.3436, P<0.0001 in Wang data set), but positively correlated with BRCA1 (Pearson correlation coefficient=0.1728, P=0.0029 in NKI data set and Pearson correlation coefficient=0.1805, P=0.0022 in Wang data set). Low TRPS-1 expression associated with poor overall survival (hazard ratio 1.79, 95% CI of ratio 0.9894 to 3.238, P=0.054) and relapse-free survival (hazard ratio 1.913, 95% CI of ratio 1.159 to 3.156, P<0.05). The low TRPS-1 mRNA levels predicted poor outcome in breast cancer patients by the 70-gene signature.ConclusionThe strong expression of TRPS-1 may serve as a good prognostic marker in breast cancer.

Key words: ductal epithelial cells, trichorhinophalangeal syndrome 1 gene, Slug, epithelial mesenchymal transition, breast cancer

基金资助: Supported by grants from Chinese National Science Fund for Young Scholars (81101707), Traditional Chinese Medicine Foundation Project of Zhejiang Province (2011ZA104), and Science and Technology Bureau of Jiaxing (2012AY1071-2).

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