Establish Albumin-creatinine Ratio Reference Valueof Adults in the Rural Area of Hebei Province△

doi:10.1016/S1001-9294(16)30018-9

Chinese Medical Sciences Journal ›› 2016, Vol. 31 ›› Issue (1): 23-30.doi: 10.1016/S1001-9294(16)30018-9

Establish Albumin-creatinine Ratio Reference Valueof Adults in the Rural Area of Hebei Province^△

Qiao-jing Liang¹, Wen Huang^1*, Guo-juan Zhang¹, Ning-li Wang^2,*

1Department of Nephrology,
2Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

收稿日期:2015-07-20 出版日期:2016-03-20 发布日期:2016-03-20

Establish Albumin-creatinine Ratio Reference Valueof Adults in the Rural Area of Hebei Province

Qiao-jing Liang¹, Wen Huang^1*, Guo-juan Zhang¹, Ning-li Wang^2,*

1Department of Nephrology,
2Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Received:2015-07-20 Published:2016-03-20 Online:2016-03-20
Contact: Wen Huang, E-mail: 25911412@163.com, Ning-li Wang, E-mail: wningli@vip.163.com

摘要/Abstract

Abstract:

Objective To establish albumin-creatinine ratio (ACR) reference value of the rural population in Hebei province.Methods This study enrolled 5154 participants. By excluding subjects with hypertension, diabetes, dyslipidemia, cardiovascular and cerebrovascular diseases, kidney diseases, and overweight condition, as well as those with an estimated glomerular filtration rate (eGFR)<60 ml/(min·1.73 m²), apparently healthy subjects (1168) were selected. Urine albumin was measured by using the immunoturbidimetic method, serum creatinine was measured by using Jaffe’s kinetic method on a morning spot-urine sample, and ACR was calculated. The 95th percentile of ACR in the healthy subjects was used as the normal upper limit.Results The normal upper limit of ACR was 28.71 mg/g (3.25 mg/mmol) for males and 31.85 mg/g (3.60 mg/mmol) for females. Based on this ACR reference value, the age-gender standardized prevalence of albuminuria in the rural areas of Hebei province was 12.9%.Conclusion The ACR reference value in the rural of Hebei province is higher than that of the Western population.

Key words: albumin-creatinine ratio, albuminuria, chronic kidney disease

Qiao-jing Liang, Wen Huang, Guo-juan Zhang, Ning-li Wang. Establish Albumin-creatinine Ratio Reference Valueof Adults in the Rural Area of Hebei Province[J].Chinese Medical Sciences Journal, 2016, 31(1): 23-30.

参考文献 29

1.	Jay PG, Geoge LB. Micromaluminuria: marker of vascular dysfunction, risk factor for cardiovascular disease.Vasc Med 2002; 7:35-43.
2.	Wang Q. The relationship between mircoalbuminuria and cardiovascular disease in diabetes. Cardiovasc Dis J Integr Tradit Chin West Med 2015; 3:189-91.
3.	Ren DY, Ding XY. Study on correlation between microal- buminria and cerebral arterial atherosclerosis. J Mod Med Health 2016; 32:514-6.
4.	Liu MM. Risk factors of albuminuria in diabetes mellitus. Clin J Mod Drug Appl 2016; 10:27-9.
5.	Rao XP, Xu M, Liang M, et al. Microalbuminuria prevalence in metabolic abnormalities. Chin J Health Care Med 2015: 17:489-91.
6.	Zhou L, Cai X, Li M. Plasma NT-proBNP is independently associated with albuminuria in type 2 diabetes. J Diabetes Complications 2016; Jan 23. pii: S1056-8727(16)00019-2.
7.	Lambers HJ, Brinkman JW, Bakker SJ, et al. Update on mi- croalbuminuria as a biomarker in renal and cardiovascular disease. Curr Opin Nephrol Hypertension 2006; 15:631-6.
8.	Gerstein HC, Mann JF, Yi Q, et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA 2001; 286:421-6.
9.	Viberti GC, Hill RD, Jarrett RJ, et al. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1982; 1:1430-2.
10	Wachtell K, Ibsen H, Olsen MH, et al. Albuminuria and cardiovascular risk in hypertensive patients with left ven- tricular hypertrophy: the LIFE study. Ann Intern Med 2003; 139:901-6.
11	National Kidney Foundation: K/DOQI clinical practice gui- delines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002; 39:S1-S266.
12	Marshall SM. Screening for microalbuminuria: which mea- surement? Diabet Med 1991; 8:706-11.
13	Witte EC, Lambers HJ, de Zeeuw D, et al. First morning voids are more reliable than spot urine samples to assess microalbuminuria. J Am Soc Nephrol 2009; 20:436-43.
14	Mattix HJ, Hsu CY, Shaykevich S. Use of the albumin/crea- tinine ratio to detect microalbuminuria: implications of sex and race. Jam Soc Nephrol 2002; 13:1034-9.
15	Dyer AR, Greenland P, Elliott P, et al. Evaluation of mea- sures of urinary albumin excretion in epidemiologic studies. Am J Epidemiol 2004; 160:1122-31.
16	Cirillo M, Laurenzi M, Mancini M, et al. Low muscular mass and overestimation of microalbuminuria by urinary albumin/creatinine ratio. Hypertension 2006; 47:56-61．
17	Liang YB, Friedman DS, Wong TY, et al. Rationale, design, methodology, and baseline data of a population-based study in rural China: the Handan eye study. Ophthalmic Epidemiol 2009; 16:115-27.
18	Committee of China adult dyslipidemia prevention guide. China adult dyslipidemia prevention guide. Chin J Cardiol 2007; 35:390-419.
19	Ma YC, Zuo L, Chen JH, et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 2006; 17:2937-44.
20	Lee K, Kim J. Estimated glomerular filtration rate and albuminuria in Korean population evaluated for cardiova- scular risk. Int Urol Nephrol 2016; 23:1-6.
21	Tazeen HJ, Nish C, Juanita H. Use of albumin creatinine ratio and urine albumin concentration as a screening test for albuminuria in an Indo-Asian population. Nephrol Dial Transplant 2007; 22:2194-200.
22	Na N, Jiang H. Research progress of urine albumin-creatinine ratio in type 2 diabetes mellitus. Chin J Clin 2015; 9: 3969-72.
23	Glassock RJ. Control of albuminuria in overt diabetic neph- ropathy: durability counts. Nephrol Dial Transplant 2016; 6:4-6.
24	Deurenberg P, Deurenberg-Yap M, Guricci S. Asians are different from Caucasians and from each other in their body mass index/body fat percent relationship. Obes Rev 2002; 3:141-6.
25	James GD, Jean ES. A longitudinal study of urinary creatinine and creatinine clearance in normal subjects. Race, sex, and age differences. Am J Hypertens 1988; 1:124-31.
26	Bakker AJ. Detection of microalbuminuria: receiver operating characteristic curve analysis favors albumin-to-creatinine ratio over albumin concentration. Diabetes Care 1999; 22:307-13.
27	Houlihan CA, Tsalamandris C, Akdeniz A, et al. Albumin to creatine ratio: a screening test with limitation. AJKD 2002; 39:1183-9.
28	Crews DC, William WM, Shoham DA. Low income and albuminuria among REGARDS (Reasons for Geographic and Racial Differences in Stroke) study participants. Am J Kidney Dis 2012; 60:779-86.
29	Li Y, Zhou LT, Liu FY. Epidemiologic study of chronic kidney disease in Changsha county of Hunan province. Chin J Nephrol 2010; 26:9-14.

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