Chinese Medical Sciences Journal ›› 2013, Vol. 28 ›› Issue (1): 58-60.doi: 10.1016/S1001-9294(13)60021-8
• Short Communication • 上一篇 下一篇
Bao-zhi Fang1,2, Guang-sheng He1*, Hai-xia Zhou1, Hui-rong Chang1, De-pei Wu1, Ai-ning Sun1, and Su-ning Chen1
Bao-zhi Fang1,2, Guang-sheng He1*, Hai-xia Zhou1, Hui-rong Chang1, De-pei Wu1, Ai-ning Sun1, and Su-ning Chen1
摘要:
APLASTIC anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes, resulting in the apoptosis of hematopoietic cells and bone marrow failure. 1 Currently, hematopoietic stem cell transplantation (HSCT), immunosuppressive - therapy (IST), and supportive care (e.g. transfusion adjuvant therapy, hematopoietic growth factors, and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST. 2 This article reported a severe AA patient who failed to respond to IST, but achieved spontaneous remission three times after granulocyte transfusions from related donors. Such cases have rarely been reported. Existence of human leukocyte antigen (HLA) cross between the patient and his relatives may influence the T cell-mediated immunity, which might explain this patient’s recovery.