Chinese Medical Sciences Journal ›› 2013, Vol. 28 ›› Issue (1): 58-60.doi: 10.1016/S1001-9294(13)60021-8

• Short Communication • 上一篇    下一篇

Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△

Bao-zhi Fang1,2, Guang-sheng He1*, Hai-xia Zhou1, Hui-rong Chang1, De-pei Wu1, Ai-ning Sun1, and Su-ning Chen1   

  1. 1 Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; 2 The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital), Suzhou 215002, China
  • 收稿日期:2012-06-11 出版日期:2013-03-26 发布日期:2013-03-26
  • 作者简介:Corresponding author Tel/Fax: 86-512-65113556, E-mail: heguangsheng@medmail.com.cn

Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△

Bao-zhi Fang1,2, Guang-sheng He1*, Hai-xia Zhou1, Hui-rong Chang1, De-pei Wu1, Ai-ning Sun1, and Su-ning Chen1   

  1. 1 Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; 2 The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital), Suzhou 215002, China
  • Received:2012-06-11 Published:2013-03-26 Online:2013-03-26
  • About author:Corresponding author Tel/Fax: 86-512-65113556, E-mail: heguangsheng@medmail.com.cn

摘要:

APLASTIC anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes, resulting in the apoptosis of hematopoietic cells and bone marrow failure. 1 Currently, hematopoietic stem cell transplantation (HSCT), immunosuppressive - therapy (IST), and supportive care (e.g. transfusion adjuvant therapy, hematopoietic growth factors, and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST. 2 This article reported a severe AA patient who failed to respond to IST, but achieved spontaneous remission three times after granulocyte transfusions from related donors. Such cases have rarely been reported. Existence of human leukocyte antigen (HLA) cross between the patient and his relatives may influence the T cell-mediated immunity, which might explain this patient’s recovery.

关键词: aplastic anemia, granulocyte transfusion, spontaneous remission, related donor

Abstract:

APLASTIC anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes, resulting in the apoptosis of hematopoietic cells and bone marrow failure. 1 Currently, hematopoietic stem cell transplantation (HSCT), immunosuppressive - therapy (IST), and supportive care (e.g. transfusion adjuvant therapy, hematopoietic growth factors, and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST. 2 This article reported a severe AA patient who failed to respond to IST, but achieved spontaneous remission three times after granulocyte transfusions from related donors. Such cases have rarely been reported. Existence of human leukocyte antigen (HLA) cross between the patient and his relatives may influence the T cell-mediated immunity, which might explain this patient’s recovery.

Key words: aplastic anemia, granulocyte transfusion, spontaneous remission, related donor

基金资助:

△Supported by Key Provincial Talents Program of Jiangsu (H201126), the Natural Science Fund for Colleges and Unive- rsities of Jiangsu Province (09KJB320015), Key Projects in the National Science & Technology Pillar Program (2008BAI61B02 and 2008ZX09312-026), the Priority Academic Program Develop- ment of Jiangsu Higher Education Institutions (PAPD).

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