Chinese Medical Sciences Journal ›› 0, Vol. ›› Issue (): 205-210.doi: 10.24920/003490

• • 上一篇    

GSTT1纯合子缺失与胰腺癌风险关系的Meta分析

崔君鹏1,林美艺2,刘正昊3,刘宝林1,*()   

  1. 1 中国医科大学附属盛京医院普外科第六科,沈阳 110004,中国
    2 中国医科大学附属第一医院风湿科,沈阳 110001,中国
    3 中国医科大学,沈阳 110013,中国
  • 收稿日期:2018-12-20 出版日期:2019-10-25 发布日期:2019-10-25
  • 通讯作者: 刘宝林 E-mail:liubl@sj-hospital.org

Association between GSTT1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis

Cui Junpeng1,Lin Meiyi2,Liu Zhenghao3,Liu Baolin1,*()   

  1. 1 Sixth Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China
    2 Department of Rheumatology, First Affiliated Hospital of China Medical University, Shenyang 110001, China
    3 China Medical University, Shenyang 110013, China
  • Received:2018-12-20 Published:2019-10-25 Online:2019-10-25
  • Contact: Liu Baolin E-mail:liubl@sj-hospital.org

摘要:

目的 探讨GSTT1纯合缺失与胰腺癌易感性的关系。

方法 检索PubMed database,CNKI,EMBASE数据库(发表日期截至2018年4月18日)中评价GSTT1基因纯合子缺失与胰腺癌关系的研究。采用RevMan5.3和Stata12.0软件分析胰腺癌患者和健康对照发生GSTT1基因纯合子缺失的频率,并计算OR值和95%置信区间(95% CI)。

结果 共有9篇文献纳入此项Meta分析。共包括5952例受试者,其中胰腺癌患者2387例,健康对照3565例。与对照组相比,胰腺癌患者发生GSTT1纯合子缺失的频率更高(33.4%比38.7%,OR=1.26,95% CI=1.01-1.58,P=0.04)。

结论 GSTT1纯合性缺失个体可能具有更高的胰腺癌易感性。

关键词: 胰腺癌, 基因, GSTT1, 易感性

Abstract:

Objective To clarify the possible association of GSTT1 homozygous deletion with the susceptibility to pancreatic cancer.

Methods We searched PubMed database, Chinese Journal Full Text Database (CNKI), and EMBASE to find the eligible studies published up to April 18, 2018 for evaluating the relationship between GSTT1 homozygous deletion and pancreatic cancer. The frequency of null genotype for GSTT1 between the pancreatic cancer group and the healthy control group was compared with Chi-square test, and odds ratios (ORs) value and 95% confidence interval (95% CI) were calculated.

Results A total of 9 studies met the inclusion criteria, and 5952 cases consisting of 2387 pancreatic cancer patients and 3565 healthy controls were included in the meta analysis. Compared with the control group, frequency of null genotype for GSTT1 in the pancreatic cancer group was higher (33.4% vs. 38.7%, OR = 1.26, 95%CI = 1.01-1.58, P = 0.04).

Conclusion GSTT1 homozygous deletion individuals may have higher susceptibility to pancreatic cancer.

Key words: pancreatic cancer, gene, GSTT1, susceptibility, meta analysis

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