GSTT1纯合子缺失与胰腺癌风险关系的Meta分析

doi:10.24920/003490

摘要/Abstract

摘要：

目的探讨GSTT1纯合缺失与胰腺癌易感性的关系。

方法检索PubMed database,CNKI,EMBASE数据库（发表日期截至2018年4月18日）中评价GSTT1基因纯合子缺失与胰腺癌关系的研究。采用RevMan5.3和Stata12.0软件分析胰腺癌患者和健康对照发生GSTT1基因纯合子缺失的频率,并计算OR值和95％置信区间（95% CI）。

结果共有9篇文献纳入此项Meta分析。共包括5952例受试者,其中胰腺癌患者2387例,健康对照3565例。与对照组相比,胰腺癌患者发生GSTT1纯合子缺失的频率更高（33.4%比38.7%,OR=1.26,95% CI=1.01-1.58,P=0.04）。

结论 GSTT1纯合性缺失个体可能具有更高的胰腺癌易感性。

关键词: 胰腺癌, 基因, GSTT1, 易感性

Abstract:

Objective To clarify the possible association of GSTT1 homozygous deletion with the susceptibility to pancreatic cancer.

Methods We searched PubMed database, Chinese Journal Full Text Database (CNKI), and EMBASE to find the eligible studies published up to April 18, 2018 for evaluating the relationship between GSTT1 homozygous deletion and pancreatic cancer. The frequency of null genotype for GSTT1 between the pancreatic cancer group and the healthy control group was compared with Chi-square test, and odds ratios (ORs) value and 95% confidence interval (95% CI) were calculated.

Results A total of 9 studies met the inclusion criteria, and 5952 cases consisting of 2387 pancreatic cancer patients and 3565 healthy controls were included in the meta analysis. Compared with the control group, frequency of null genotype for GSTT1 in the pancreatic cancer group was higher (33.4% vs. 38.7%, OR = 1.26, 95%CI = 1.01-1.58, P = 0.04).

Conclusion GSTT1 homozygous deletion individuals may have higher susceptibility to pancreatic cancer.

Key words: pancreatic cancer, gene, GSTT1, susceptibility, meta analysis

Cui Junpeng, Lin Meiyi, Liu Zhenghao, Liu Baolin. Association between GSTT1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis[J].Chinese Medical Sciences Journal, 2019, 34(3): 205-210.

图/表 6

参考文献 27.

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Study	Year of publication	Ethnics	Country	Genotyping methods	Control group (number of cases)		Case group (number of cases)
Study	Year of publication	Ethnics	Country	Genotyping methods	Null GSTT1	Present GSTT1	Null GSTT1	Present GSTT1
Liu et al¹⁶	2000	Caucasian	Canada	PCR	26	99	30	119
Duell et al¹⁵	2002	Caucasian	America	Multiplex PCR	149	704	46	214
Duell et al¹⁵	2002	African	America	Multiplex PCR	8	28	5	21
Duell et al¹⁵	2002	Asian	America	Multiplex PCR	21	31	9	8
Cheng et al¹⁷	2003	Asian	China	PCR	174	162	160	156
Jiao et al¹⁸	2007	Caucasian	America	Multiplex PCR	67	248	74	271
Guo et al¹⁹	2008	Asian	China	Multiplex PCR	269	316	164	174
Vrana et al⁹	2009	Caucasian	Czech	Real-time PCR	39	308	45	199
Zhang et al²⁰	2010	Asian	China	Multiplex PCR	67	83	104	46
Jiang et al²¹	2011	Asian	China	Duplex PCR	180	186	120	62
Yamada et al²²	2014	Asian	Japan	Real-time PCR	191	209	167	193

Items	Liu et al¹⁶	Duell et al¹⁵	Cheng et al¹⁷	Jiao et al¹⁸	Guo et al¹⁹	Vrana et al⁹	Zhang et al²⁰	Jiang et al²¹	Yamada et al²²
Selection
Is the case definition adequate?	1	1	1	1	1	1	1	1	1
Representativeness of the exposed cohort	1	1	0	1	0	1	1	0	1
Selection of the Controls	1	1	1	1	0	1	0	0	1
Definition of the Controls	1	1	0	1	1	1	0	1	0
Comparability
The study controls the most important confounding factors	0	1	1	0	1	0	1	1	1
The study controls other important confounding factors	1	1	0	1	0	0	0	0	1
Exposure
Ascertainment of exposure	1	1	1	1	1	1	1	1	1
Same method of ascertainment for the Cases and Controls	1	1	1	1	1	1	1	1	1
Non-response rate	1	1	1	1	1	1	1	1	1
Total score	8	9	6	8	6	7	6	6	8

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