Chinese Medical Sciences Journal ›› 2021, Vol. 36 ›› Issue (3): 173-186.doi: 10.24920/003984

所属专题: 人工智能与精准肿瘤学

• 综述 • 上一篇    下一篇

多组学技术及其在肝细胞癌中的临床应用:当前进展与未来机遇

杨万水1,蒋涵羽2,刘超3,4,魏靖伟5,6,7,周宇5,6,7,8,宫鹏云3,4,宋彬2,*(),田捷3,4,5,6,9,*()   

  1. 1安徽医科大学公共卫生学院营养与食品卫生学系,合肥 230032,中国
    2四川大学华西医院放射科,成都 610041,中国
    3北京航空航天大学北京大数据与精准医疗高精尖创新中心,北京 100191,中国
    4北京航空航天大学大数据精准医疗工信部重点实验室,北京 100191,中国
    5中国科学院自动化研究所中国科学院分子影像重点实验室,北京 100190,中国
    6分子影像北京市重点实验室,北京 100190,中国
    7中国科学院大学,北京 100049,中国
    8西安电子科技大学生命科学学院,西安 710126, 中国
    9西安电子科技大学生命科学技术学院和分子与神经影像教育部工程研究中心,西安 710126, 中国
  • 收稿日期:2021-08-16 接受日期:2021-09-14 出版日期:2021-09-30 发布日期:2021-09-17
  • 通讯作者: 宋彬,田捷 E-mail:anicesong@vip.sina.com;jie.tian@ia.ac.cn

Multi-Omics and Its Clinical Application in Hepatocellular Carcinoma: Current Progress and Future Opportunities

Wanshui Yang1,Hanyu Jiang2,Chao Liu3,4,Jingwei Wei5,6,7,Yu Zhou5,6,7,8,Pengyun Gong3,4,Bin Song2,*(),Jie Tian3,4,5,6,9,*()   

  1. 1Department of Nutrition, School of Public Health, Anhui Medical University, Hefei 230032, China
    2Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China
    3Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering, Beihang University, Beijing 100191, China
    4Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology, Beijing 100191, China
    5Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
    6Beijing Key Laboratory of Molecular Imaging, Beijing 100190, China
    7University of Chinese Academy of Sciences, Beijing 100049, China
    8School of Life Science and Technology, Xidian University, Xi’an 710126, China
    9Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an 710126, China
  • Received:2021-08-16 Accepted:2021-09-14 Online:2021-09-30 Published:2021-09-17
  • Contact: Bin Song,Jie Tian E-mail:anicesong@vip.sina.com;jie.tian@ia.ac.cn

摘要:

全球范围内,肝细胞癌(Hepatocellular carcinoma, HCC)是第六大常见恶性肿瘤,也是癌症相关死亡的第四大原因。中国HCC病例占全球病例的50%以上,导致HCC成为重要的公共卫生问题。尽管HCC诊断和治疗取得了进步,但高复发率仍然是HCC治愈的主要障碍。目前,多组学技术的融合促进了临床上疾病的监测、精准诊断和个体化治疗。无创的影像组学利用术前影像图像反映特定临床结局相关的细微像素级的模式变化。影像组学已广泛应用于预测组织病理学诊断、评估治疗反应和预测疾病预后。高通量测序技术和基因表达谱分析使基因组学和蛋白质组学能够识别HCC中不同的转录组亚型和反复性的遗传改变,这将揭示病理生理学上复杂的疾病发生过程。医学大数据的积累和人工智能技术的发展使我们更好地从多组学的角度深入理解HCC的发病机制,并显示出将HCC的外科治疗或介入治疗转化为抗肿瘤发生机制治疗的潜力,这将极大地推动HCC精准诊疗的发展。

关键词: 肝细胞癌, 影像组学, 蛋白质组学, 基因组学, 多组学

Abstract:

Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the fourth leading cause of cancer related death worldwide. China covers over half of cases, leading HCC to be a vital threaten to public health. Despite advances in diagnosis and treatments, high recurrence rate remains a major obstacle in HCC management. Multi-omics currently facilitates surveillance, precise diagnosis, and personalized treatment decision making in clinical setting. Non-invasive radiomics utilizes preoperative radiological imaging to reflect subtle pixel-level pattern changes that correlate to specific clinical outcomes. Radiomics has been widely used in histopathological diagnosis prediction, treatment response evaluation, and prognosis prediction. High-throughput sequencing and gene expression profiling enabled genomics and proteomics to identify distinct transcriptomic subclasses and recurrent genetic alterations in HCC, which would reveal the complex multistep process of the pathophysiology. The accumulation of big medical data and the development of artificial intelligence techniques are providing new insights for our better understanding of the mechanism of HCC via multi-omics, and show potential to convert surgical/intervention treatment into an antitumorigenic one, which would greatly advance precision medicine in HCC management.

Key words: hepatocellular carcinoma, radiomics, proteomics, genomics, multi-omics

Copyright © 2018 Chinese Academy of Medical Sciences. All right reserved.
 
www.cmsj.cams.cn
京公安备110402430088 京ICP备06002729号-1  Powered by Magtech.

Supervised by National Health & Family Plan Commission of PRC

9 Dongdan Santiao, Dongcheng district, Beijing, 100730 China

Tel: 86-10-65105897  Fax:86-10-65133074 

E-mail: cmsj@cams.cn  www.cmsj.cams.cn

Copyright © 2018 Chinese Academy of Medical Sciences

All right reserved.

京公安备110402430088  京ICP备06002729号-1