Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (1): 79-81.doi: 10.24920/003929

• 病例报告 • 上一篇    下一篇

心脏手术中血友病患者的替代疗法:3例报告

陈小坤1,苗齐2,朱铁楠3,张超纪2,*()   

  1. 1中国医学科学院北京协和医学院北京协和医院外科,北京 100730,中国
    2中国医学科学院北京协和医学院北京协和医院心外科,北京 100730,中国
    3中国医学科学院北京协和医学院北京协和医院血液科,北京 100730,中国
  • 收稿日期:2021-05-07 接受日期:2021-10-15 出版日期:2022-03-31 发布日期:2022-03-02
  • 通讯作者: 张超纪 E-mail:chaojizhang@163.com

Replacement Therapy for Hemophilia Patients Undergoing Cardiac Surgery: Report of Three Cases

Xiaokun Chen1,Qi Miao2,Tienan Zhu3,Chaoji Zhang2,*()   

  1. 1Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    2Department of Cardiac Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    3Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  • Received:2021-05-07 Accepted:2021-10-15 Published:2022-03-31 Online:2022-03-02
  • Contact: Chaoji Zhang E-mail:chaojizhang@163.com

摘要:

血友病是一种X连锁隐性遗传性出血性疾病。近年来随着长效凝血因子及非因子治疗的问世,血友病的诊疗越来越多样化,使得血友病患者的预期寿命得到延长。但血友病患者血液中的凝血因子减少并不会减慢动脉粥样硬化的进展。随着预期寿命的增加,越来越多的血友病患者将患上与年龄相关的心血管疾病,并且将需要外科手术干预。由于心脏手术需要肝素化和体外循环,血友病患者的止血和凝血平衡极具挑战性。本文报告了三例成功接受心脏手术的血友病患者。

关键词: 血友病, 心脏手术, 替代疗法

Abstract:

Hemophilia is an X-linked recessive inherited bleeding disorder. Despite the improved treatment in recent years with the advent of replacement therapies, the progression of atherosclerosis is not slowed down after the reduction of clotting factors in hemophilia. As life expectancy increases, more hemophilia patients will suffer from age-related cardiovascular diseases. Since cardiac surgery needs heparinization and cardiopulmonary bypass (CPB), it is extremely challenging to balance hemostasis and coagulation in patients with hemophilia. Here we report three cases of hemophilia patients who underwent cardiac surgery successfully.

Key words: Hemophilia, cardiac surgery, replacement therapy

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