Chinese Medical Sciences Journal ›› 2017, Vol. 32 ›› Issue (4): 253-259.doi: 10.24920/J1001-9294.2017.037

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武文1, 李燕2, 徐敦全3,*()   

  1. 1 陆军总医院超声科,北京,100007
    2 陆军总医院体检中心,北京,100007
    3 陆军医科大学附属新桥医院日喀则分院临床实验室,日喀则, 西藏,857000
  • 收稿日期:2016-10-24 出版日期:2017-12-30 发布日期:2017-12-30
  • 通讯作者: 徐敦全

Role of ROS/Kv/HIF Axis in the Development of Hypoxia-Induced Pulmonary Hypertension

Wu Wen1, Li Yan2, Xu Dunquan3,*()   

  1. 1 Department of Ultrasound, General Hospital of the Army, Beijing 100007, China
    2. Medical Examination Center, General Hospital of the Army, Beijing 100007, China
    3 Clinical Laboratory, the Xigaze Branch of Xinqiao Hospital, the Army Medical University, Xigaze, Tibet 857000, China
  • Received:2016-10-24 Published:2017-12-30 Online:2017-12-30
  • Contact: Xu Dunquan



关键词: 低氧性肺动脉高压, 活性氧簇, 低氧诱导因子, 钾离子, 血管收缩, 血管重构


Hypoxic pulmonary hypertension (HPH) is a common complication in patients with chronic obstructive pulmonary disease (COPD), sleep-disordered breathing, or dwellers in high altitude. The exact mechanisms underlying the development of HPH still remain unclear. Reactive oxygen species (ROS), hypoxia inducible factors (HIF), and potassium channels (KV) are believed as the main factors during the development of HPH. We propose that the “ROS/Kv/HIF axis” may play an important initiating role in the development of HPH. Being formed under a hypoxic condition, ROS affects the expression and function of HIFs or KV, and consequently triggers multiple downstream signaling pathways and genes expression that participate in promoting pulmonary vasoconstriction and arterial remodeling. Thus, further study determining the initiating role of “ROS/Kv/HIF axis” in the development of HPH could provide theoretic evidences to better understand the underlying mechanisms of HPH, and help identify new potential targets in the treatment of HPH.

Key words: hypoxia-induced pulmonary hypertension, reactive oxygen species, hypoxia inducible factors, potassium channels, vasoconstriction, arterial remodeling

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