Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (1): 73-78.doi: 10.24920/003990

• Review • Previous Articles     Next Articles

Research Advances in the Role of Keratins in Gastrointestinal Cancer

Siwen Ouyang1, 2, Weiming Kang2, *()   

  1. 1Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100010, China
  • Received:2021-08-30 Accepted:2021-12-23 Published:2022-03-31 Online:2022-03-10
  • Contact: Weiming Kang

The incidence and mortality rates of gastrointestinal (GI) cancer remain high. Despite constant improvements in diagnostic and therapeutic techniques, the early diagnosis, mid- and late-stage treatment, drug tolerance, and cancer recurrence and metastasis in GI cancer remain challenging. In this review article we summarize the recent research advance in the roles of keratins in GI cancer, with the hope that they will become efficient biomarkers for the prediction, diagnosis, or treatment of these malignancies.

Key words: Keratin, gastrointestinal cancer, diagnostic significance, mechanism


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