Chinese Medical Sciences Journaldoi: 10.24920/003994

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Dual Role of Wnt5a in the Progression of Inflammatory Diseases

Xu Chen, Hongling Liu, Dehong Li, Jinsui Wang, Fenghui Zhao   

  1. 1 Department of Pathology, Gansu Provincial Hospital, Lazhou 730000, China 
    2 Department of Occupational Medicine, The Third Gansu Provincial Hospital, Lanzhou 730000, China
    3 Department of Clinical Laboratory, Gansu Provincial Hospital, Lanzhou 730000, China
  • Received:2021-09-09 Accepted:2022-03-06 Published:2022-05-11 Online:2022-05-11

Wnt5a is a secreted Wnt ligand that plays a critical role in cellular pathways and inflammatory diseases. The WNT5A gene encodes two protein isoforms, Wnt5a-long and Wnt5a-short, which differ based on different promoter methylation and have distinct functions. However, the mechanisms of the promoter methylation are unclear. Depending on the extent of promoter methylation, Wnt5a exerts both anti-inflammatory and pro-inflammatory effects in inflammatory diseases, which may be involved in different Wnt5a isoforms. Therefore, the Wnt5a isoforms may be potential diagnostic markers for inflammatory diseases and the mechanisms of the WNT5A gene promoter methylation need to be further investigated.

Key words: Wnt5a, inflammatory diseases, promoter methylation

Funding: Gansu Health and Family Planning Commission Funding (GSWSKY 2018-34)

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