Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (2): 103-117.doi: 10.24920/004066

• Original Article • Previous Articles     Next Articles

Association Between Lipid Profiles and Left Ventricular Hypertrophy: New Evidence from a Retrospective Study

Xuewei Huang1, 5, Keqiong Deng2, 3, 4, Juanjuan Qin1, 5, Fang Lei5, 6, Xingyuan Zhang5, 6, Wenxin Wang1, 5, Lijin Lin1, 5, Yuming Zheng7, Dongai Yao8, Huiming Lu9, Feng Liu10, Lidong Chen11, Guilan Zhang12, Yueping Liu13, 14, Qiongyu Yang15, Jingjing Cai16, Zhigang She1, 5, *(), Hongliang Li1, 3, 5, *()   

  1. 1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    2Department of Cardiology, Center Hospital of Huanggang, Huanggang, Hubei 438000, China
    3Huanggang Institute of Translation Medicine, Huanggang, Hubei 438000, China
    4Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
    5Institute of Model Animal, Wuhan 430071, China
    6School of Basic Medical Science, Wuhan University, Wuhan 430071, China
    7Physical Examination Center, The Central Hospital of Wuhan, Wuhan 430014, China
    8Physical Examination Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
    9General Medical Department, CR & WISCO General Hospital, Wuhan 430000, China
    10Information Center, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan 430015, China
    11Department of Medical Examination Center, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China
    12Department of Health Management, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei 432000, China
    13Basic Medical Laboratory, General Hospital of Central Theater Command, Wuhan 430070, China
    14Hubei Key Laboratory of Central Nervous System Tumor and Intervention, Wuhan 430070, China
    15Chinese Medicine Center, Shiyan Renmin Hospital, Shiyan, Hubei 442000, China
    16Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410000, China
  • Received:2022-01-22 Accepted:2022-03-01 Published:2022-06-30 Online:2022-03-02
  • Contact: Zhigang She,Hongliang Li;

Objective To explore the association between lipid profiles and left ventricular hypertrophy in a Chinese general population.
Methods We conducted a retrospective observational study to investigate the relationship between lipid markers [including triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein (HDL) cholesterol, non-HDL-cholesterol, apolipoprotein A-I, apolipoprotein B, lipoprotein[a], and composite lipid profiles] and left ventricular hypertrophy. A total of 309,400 participants of two populations (one from Beijing and another from nationwide) who underwent physical examinations at different health management centers between 2009 and 2018 in China were included in the cross-sectional study. 7,475 participants who had multiple physical examinations and initially did not have left ventricular hypertrophy constituted a longitudinal cohort to analyze the association between lipid markers and the new-onset of left ventricular hypertrophy. Left ventricular hypertrophy was measured by echocardiography and defined as an end-diastolic thickness of the interventricular septum or left ventricle posterior wall > 11 mm. The Logistic regression model was used in the cross-sectional study. Coxmodel and Coxmodel with restricted cubic splines were used in the longitudinal cohort.
Results In the cross-sectional study, for participants in the highest tertile of each lipid marker compared to the respective lowest, triglycerides [odds ratio (OR): 1.250, 95%CI: 1.060 to 1.474], HDL-cholesterol (OR: 0.780, 95%CI: 0.662 to 0.918), and lipoprotein(a) (OR: 1.311, 95%CI: 1.115 to 1.541) had an association with left ventricular hypertrophy. In the longitudinal cohort, for participants in the highest tertile of each lipid marker at the baseline compared to the respective lowest, triglycerides [hazard ratio (HR): 3.277, 95%CI: 1.720 to 6.244], HDL-cholesterol (HR: 0.516, 95%CI: 0.283 to 0.940), non-HDL-cholesterol (HR: 2.309, 95%CI: 1.296 to 4.112), apolipoprotein B (HR: 2.244, 95%CI: 1.251 to 4.032) showed an association with new-onset left ventricular hypertrophy. In the Coxmodel with forward stepwise selection, triglycerides were the only lipid markers entered into the final model.
Conclusion Lipids levels, especially triglycerides, are associated with left ventricular hypertrophy. Controlling triglycerides level potentiate to be a strategy in harnessing cardiac remodeling but deserve to be further investigated.

Key words: left ventricular hypertrophy, lipid, triglycerides, apolipoprotein

Copyright © 2021 Chinese Academy of Medical Sciences.  京公安备110402430088  京ICP备06002729号-1  Powered by Magtech.

Supervised by National Health & Family Plan Commission of PRC

9 Dongdan Santiao, Dongcheng district, Beijing, 100730 China

Tel: 86-10-65105897  Fax:86-10-65133074 


Copyright © 2018 Chinese Academy of Medical Sciences

All right reserved.

京公安备110402430088  京ICP备06002729号-1