Chinese Medical Sciences Journal ›› 2017, Vol. 32 ›› Issue (2): 113-118.doi: 10.24920/J1001-9294.2017.014

• Review • Previous Articles     Next Articles

The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars

Li Zifei1, Liu Qingliang2, Wang Xiaojun2, *(), Luan Jie1, *()   

  1. 1Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
    2Division of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China
  • Received:2016-06-27 Online:2017-06-20 Published:2017-06-10
  • Contact: Wang Xiaojun,Luan Jie E-mail:wxjpumch@163.com;JieLuands@163.com

Abstract:

Blood supply is believed to be an important aspect in the development of pathological scars. However, there are controversies about vascular distribution, vascular structure and blood flow in pathological scars. Additionally, hypoxic microenvironment plays an important role in the vascularization of pathological scar tissues, and hypoxic conditions can be reflected by metabolic indexes and some cytokines. Furthermore, the correlation between blood supply and tissue hypoxia is controversial. The aim of this article is to review the literature on the characteristics of blood supply and tissue hypoxia in pathological scars, from which we can see pathological scars have unique characteristics of blood supply that are closely associated with tissue hypoxia. Moreover, development in the treatment of pathological scars is herein reviewed.

Key words: pathological scar, hypertrophic scar, keloid, blood flow, hypoxia

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