杓型与非杓型高血压患者的血浆干细胞因子及其受体表达水平研究

doi:10.24920/J1001-9294.2017.035

Abstract

Objective

The aim of this study was to investigate the relationship between peripheral plasma stem cell factor (SCF)/c-kit levels and the types of dipper and non-dipper hypertension in hypertensive patients.

Methods

This cross-sectional study included newly diagnosed hypertensive patients who underwent 24-hour ambulatory blood pressure monitor (ABPM) between January 2009 and 2012 in Jiangning city. Patients were divided into the dipper group and the non-dipper group according to ABPM measurements. The levels of SCF and its receptor c-kit, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in peripheral blood were measured via enzyme-linked immunosorbent assays. The serum levels of glucose and lipid were examined as well. The levels of SCF/c-kit were compared between the dippers and the non-dippers; and their correlation with 24-hour mean systolic blood pressure (MSBP), 24-hour mean diastolic blood pressure (MDBP), TNF-α and IL-6 were investigated using linear regression analyses statistically.

Results

A total of 247 patients with newly diagnosed hypertension were recruited into the study, including 116 non-dippers and 131 dippers. The levels of peripheral plasma SCF were higher in non-dipper group (907.1±52.7 ng/L vs. 778.7±44.6 ng/L; t=2.837, P<0.01), and the levels of c-kit were higher in non-dipper group too (13.2±1.7 μg/L vs 9.57±1.4 μg/L; t=2.831, P<0.01). Linear regression analysis revealed that SCF/c-kit levels were significantly positively correlated with MSBP, MDBP, plasma TNF-α, and IL-6 levels (all P<0.01).

Conclusions

Peripheral plasma SCF/c-kit levels are higher in patients with non-dipper hypertension than those with dipper one, and significantly correlate with 24-hour MSBP, 24-hour MDBP, serum TNF-α and IL-6 levels.

Key words: ambulatory blood pressure monitor, dipper hypertension, non-dipper hypertension, stem cell factor, c-kit

Zhong Hailan, Xu Chongli, Chen Guangsheng, Chen Xiumei. Plasma SCF/c-kit Levels in Patients with Dipper and Non-Dipper Hypertension[J].Chinese Medical Sciences Journal, 2017, 32(4): 232-238.

Figures/Tables 2

Table 1

Figure 1.

References 29.

1.	Pickering TG, White WB, American Society of Hypertension Writing Group. When and how to use self (home) and ambulatory blood pressure monitoring. J Am Soc Hypertens 2008; 2: 119-24. doi: 10.1016/j.jash.2008. 04.002.
2.	Dolan E, Stanton A, Thijs L, Hinedi K, Atkins N, McClory S, et al. Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin Outcome Study. Hypertension 2005; 46: 156-61. doi: 10. 1161/01.HYP.0000170138.56903.7a.
3.	Fagard RH, Celis H, Thijs L, Staessen JA, Clement DL, De Buyzere ML, et al.Daytime and nighttime blood pressure as predictors of death and cause-specific cardiovascular events in hypertension. Hypertension 2008; 51: 55-61. doi: 10.1161/HYPERTENSION AHA.107.100727.
4.	Boggia J, Li Y, Thijs L, Hansen TW, Kikuya M, Björklund-Bodegard K, et al.International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcomes (IDACO) investigators. Prognostic accuracy of day versus night ambulatory blood pressure: A cohort study. Lancet 2007; 370: 1219-29. doi: 10.1016/ S0140-6736(07)61538-4.
5.	Forstermann U, Munzel T.Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006; 113: 1708-14. doi: 10.1161/CIRCULATIONAHA. 105.602532.
6.	Dong Y, Clément C, Céline L, José V, Barend M, Micheline D, et al.Hypertension impairs postnatal vasculogenesis: role of antihypertensive agents. Hypertension 2008; 51: 1537-44. doi: 10.1161/HYPERTENSIONAHA.107.109066.
7.	Feng ZC, Riopel M, Popell A, Wang R.A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase. Diabetologia 2015; 58: 654-65. doi: 10.1007/s00125-015-3504-0.
8.	Sun YG, Gracias NG, Drobish JK, Vasko MR, Gereau RW, Chen ZF.The c-kit signaling pathway is involved in the development of persistent pain. Pain 2009; 144: 178-86. doi: 10.1016/j.pain.2009.04.011.
9.	Jin QH, Shen HX, Wang H, Shou QY, Liu Q.Curcumin improves expression of SCF/c-kit through attenuating oxidative stress and NF-κB activation in gastric tissues of diabetic gastroparesis rats. Diabetol Metab Syndr 2013; 5: 12. doi: 10.1186/1758-5996-5-12.
10.	Liu G, Chen ZY, Ma L, Lou X, Li SJ, Wang YL.Intracranial hemangiopericytoma: MR imaging findings and diagnostic usefulness of minimum ADC values. J Magn Reson Imaging 2013; 38:1146-51. doi: 10.1002/jmri.24075.
11.	Zhong HL, Lu XZ, Chen XM, Yang XH, Zhang HF, Zhou L, et al.Relationship between stem cell factor/c-kit expression in peripheral blood and blood pressure. J Hum Hypertens 2010; 24: 220-5. doi: 10.1038/jhh.2009.62.
12.	Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm M, et al.Task Force Members. 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 31: 2181-357. doi: 10.1097/01.hjh.0000431740. 32696.cc.
13.	Liang J, Wu YL, Chen BJ, Zhang W, Tanaka Y, Sugiyama H.The c-kit receptor-mediated signal transduction and tumor-related diseases. Int J Biol Sci 2013; 9: 435-43. doi: 10.7150/ijbs. 6087.
14.	Coffman TM.Under pressure: the search for the essential mechanisms of hypertension. Nat Med 2011; 17:1402-9. doi: 10.1038/nm.2541.
15.	Mikolajczyk TP, Nosalski R, Szczepaniak P, Budzyn K, Osmenda G, Skiba D, et al.Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension. FASEB J 2016; 30: 1987-99. doi: 10.1096/fj.201500088R.
16.	Woo JS, Jang WS, Kim HS, Lee JH, Choi EY, Kim JB, et al.Comparison of peripheral arterial tonometry and flow-mediated vasodilation for assessment of the severity and complexity of coronary artery disease. Coron Artery Dis 2014; 25: 421-6. doi: 10.1097/MCA.0000000000000094.
17.	de la Sierra A, Redon J, Banegas JR, Segura J, Parati G, Gorostidi M, et al. Prevalence and factors associated with circadian blood pressure patterns in hypertensive patients. Hypertension 2009; 53: 466-72. doi: 10.1161/HYPERTEN SIONAHA.108.124008.
18.	Tosu AR, Demir S, Selcuk M, Kaya Y, Akyol A, Ozdemir M, et al.Comparison of inflammatory markers in non-dipper hypertension vs. dipper hypertension and in normotensive individuals: uric acid, C-reactive protein and red blood cell distribution width readings. Postepy Kardiol Interwencyjnej 2014; 10: 98-103. doi: 10.5114/pwki. 2014. 43514.
19.	Fagard RH, Celis H, Thijs L, Staessen JA, Clement DL, De Buyzere ML, et al.Daytime and nighttime blood pressure as predictors of death and cause-specific cardiovascular events in hypertension. Hypertension 2008; 51: 55-61.doi: 10.1161/HYPERTENSIONAHA.107.100727.
20.	Ozdemir E, Yildirimturk O, Cengiz B, Yurdakul S, Aytekin S.Evaluation of carotid intima-media thickness and aortic elasticity in patients with nondipper hypertension. Echocardiography 2014; 31: 663-8. doi: 10.1111/echo. 12444.
21.	Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC.Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway. J Surg Res 2004; 120: 288-94. doi: 10.1016/j.jss. 2004. 01.005.
22.	Wang CH, Verma S, Hsieh IC, Hung A, Cheng TT, Wang SY, et al.Stem cell factor attenuates vascular smooth muscle apoptosis and increases intimal hyperplasia after vascular injury. Arterioscler Thromb Vasc Biol 2007; 27:540-7. doi: 10.1161/01.ATV.0000257148.01384.7d.
23.	Yip HK, Chang LT, Chang WN, Lu CH, Liou CW, Lan MY, et al.Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke. Stroke 2008; 39: 69-74. doi: 10.1161/STROKEAHA.107.489401.
24.	Mendizábal Y, Llorens S, Nava E.Hypertension in metabolic syndrome: vascular pathophysiology. Int J Hypertens 2013; 2013:230868. doi: 10.1155/2013/230868.
25.	Lee DL, Leite R, Fleming C, Pollock JS, Webb RC, Brands MW.Hypertensive response to acute stress is attenuated in interleukin-6 knockout mice. Hypertension 2004; 44: 259-63. doi: 10.1161/01.HYP.0000139913. 56461.fb.
26.	Hivert MF, Sullivan LM, Fox CS, Nathan DM, D'Agostino RBS, Wilson PW, et al. Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance. J Clin Endocrinol Metab 2008; 93: 3165-72. doi: 10.1210/jc.2008-0425.
27.	Rabe K, Lehrke M, Parhofer KG, Broedl UC.Adipokines and insulin resistance. Mol Med 2008; 14:741-51. doi: 10.2119/2008-00058.Rabe.
28.	Sriramula S, Haque M, Majid DS, Francis J.Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy. Hypertension 2008; 51: 1345-51. doi: 10.1161/HYPERTENSIONAHA.107.102152.
29.	Wassmann S, Stumpf M, Strehlow K, Schmid A, Schieffer B, Böhm M, et al.Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ Res 2004; 94: 534-41. doi: 10.1161/01.RES.0000115557.25127.8D.

Variable	Hypertension patients		t	P
Variable	Dipper (n=131)	Non-dipper (n=116)	t	P
Smokers (%)	25（19.1）	22（19.0）	0.951	0.378
Drinkers (%)	57（43.5）	52（44.8）	0.679	0.491
BMI(kg/m²)	23.6±3.2	24.0±3.1	0.748	0.452
Urea nitrogen (mmol/L)	5.0±1.2	5.1±1.2	1.020	0.210
Creatinine (mmol/L)	67.6±12.4	68.6±13.3	0.810	0.412
Uric acid (mmol/L)	266.7±76.5	270.4±72.5	1.127	0.301
Systolic BP (mmHg)
Clinic	151.9±13.8	152.4±14.8	0.751	0.443
24-hour	131.1±11.8	133.3±13.8	1.872	0.043
Day time	136.6±12.3	135.0±14.0	1.567	0.135
Night time	115.0±11.2	128.5±14.4	2.641	0.009
Nocturnal reduction (%)	15.7±4.1	4.7±4.9	2.793	0.005
Diastolic BP (mmHg)
Clinic	93.0±9.6	92.2±10.4	0.849	0.413
24-hour	81.2±9.1	80.2±10.2	1.279	0.215
Day time	85.6±9.5	82.2±10.4	1.578	0.129
Night time	68.2±8.7	74.5±10.3	2.703	0.008
Nocturnal reduction (%)	20.4±5.6	9.1±6.4	2.656	0.009
FPG (mmol/L)	4.9±0.3	5.0±0.5	1.420	0.229
Cholesterol (mmol/L)	4.6±1.0	4.7±1.1	1.300	0.211
LDL (mmol/L)	2.8±0.9	2.9±0.9	1.001	0.301
HDL(mmol/L)	1.4±0.8	1.4±0.9	0.957	0.379
Triglycerides (mmol/L)	1.2±0.9	1.5±1.0	1.592	0.112
TNF-α(ng/L)	11.6±4.2	14.7±3.9	2.751	0.007
IL-6(mg/L)	15 550±447.3	26 860±249.5	2.827	0.006
SCF (ng/L)	778.7±44.6	907.1±52.7	2.837	0.005
c-kit (μg/L)	9.57±1.4	13.2±1.7	2.831	0.005

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