Chinese Medical Sciences Journal ›› 2016, Vol. 31 ›› Issue (2): 121-126.doi: 10.1016/S1001-9294(16)30036-0

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Relation Between Cellular Senescence and Liver Diseases

Guo-wen Li, Xue-feng Yang*, Nian Fu, Yan Ou-yang, Kai Qing   

  1. Department of Gastroenterology, the Affiliated NanhuaHospital of University of South China, Hengyang 421002, Hunan, China
  • Received:2015-09-18 Online:2016-06-20 Published:2016-06-20
  • Contact: Tel:18973405898

Abstract: Cellular senescence refers to a process that cellular proliferation and differentiation modulated by the multiple stimulating factors gradually decline. Aging cells present the irreversible stop of proliferation and differentiation and change in secretory function because the cell cycle of aging cells is steadily blocked at some point. It has have been shown that cellular senescence plays an important role in the occurrence and development of liver diseases. In this paper, we review the advances in relations between cellular senescence and liver diseases.

Key words: cellular senescence, mechanism, liver diseases, liver fibrosis, liver cancer

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