Chinese Medical Sciences Journal ›› 2016, Vol. 31 ›› Issue (4): 247-253.doi: 10.1016/S1001-9294(17)30008-1

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The Effect of Sleep Deprivation on Coronary Heart Disease

Rong Yuan1, 2, Jie Wang1, *, Li-li Guo1   

  1. 1 Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053;
    2 Beijing University of Chinese Medicine, Beijing 100029
  • Published:2016-11-20 Online:2016-11-20
  • Contact: Tel: +86 010-88001817; fax: +86 1088001817. E-mail

Sleep deprivation (SD) has been associated with an increased morbidity and mortality of coronary heart disease (CHD). SD could induce autonomic nervous dysfunction, hypertension, arrhythmia, hormonal dysregulation, oxidative stress, endothelial dysfunction, inflammation and metabolic disorder in CHD patients. This paper reviewed the study results of SD in clinical trials and animal experiments and concluded that SD was associated with cardiovascular risk factors, which aggravated CHD in pathogenesis and outcomes.

Key words: heart disease, insomnia, sleep disorder, risk factors, myocardial ischemia

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