女性生殖系统肾外肾母细胞瘤报道一例及文献回顾

doi:10.24920/J1001-9294.2017.040

Abstract

Extrarenal Wilms’ Tumors (ERWTs) are rare. There have been only 25 cases of ERWT arising from the female genital system reported in the literature. In this paper, we report a 60-year-old woman with a complaint of vaginal bleeding and a polypoid mass in the uterine cavity by sonography that was demonstrated as ERWT by pathology after resection. The pathological characteristics, histological origination, diagnosis, therapy and prognosis of ERWT in female reproductive system are discussed in this paper in the purpose of improving the diagnosis and therapy of this rare tumor.

Key words: extrarenal Wilms’, tumors, uterus, teratoid Wilms’, tumor

Cao Minmin, Huang Cuiping, Wang Yafen, Ma Demei. Extrarenal Wilms’ Tumor of the Female Genital System: A Case Report and Literature Review^△[J].Chinese Medical Sciences Journal, 2017, 32(4): 274-278.

Figures/Tables 2

Figure 1.

Table 1

References 31

[1]	Taguchi S, Shono T, Mori D, Horie H.Extrarenal Wilms’ tumor in children with unfavorable histology: a case report. J Pediatr Surg 2010; 45: e19-22. doi: 10.1016/j.jpedsurg.2010.06.004.
[2]	Rojas Y, Slater BJ, Braverman RM, Eldin KW, Thompson PA, Wesson DE, et al.Extrarenal Wilms tumor: a case report and review of the literature. J Pediatr Surg 2013; 48: e33-5. doi: 10.1016/j.jpedsurg.2013.04.021.
[3]	Chen M, Chang HK, Chang KM, Yang S.Primary prostatic Wilms' tumor: a case report. Acta Cytol 2010; 54:943-5.
[4]	Kapur VK, Sakalkale RP, Samuel KV, Meisheri IV, Bhagwat AD, Ramprasad A, et al.Association of extrarenal Wilms’ tumor with a Horseshoe kidney. J Pediatr Surg 1998; 33: 935-7. doi: 10.1016/s0022-3468(98)90678-9.
[5]	Morandi A, Fagnani AM, Runza L, Farris G, Zanini A, Parolini F, et al.Extrarenal testicular Wilms’ tumor in a 3-year-old child. Pediatr Surg Int 2013; 29: 961-4. doi: 10.1007/s00383-013-3338-0.
[6]	Hiradfar M, Shojaeian R, Zabolinejad N, Saeedi P, Joodi M, Khazaie Z, et al.Extrarenal Wilms' tumour presenting as an inguinal mass. Arch Dis Child 2012; 97:1077. doi: 10.1136/archdischild-2012-302605.
[7]	Moyson F, Maurus-Desmarez R, Gompel C.Mediastinal Wilms’ tumor? Acta Chir Belg 1961; 2:118-28.
[8]	Madanat F, Osbome B, Cangir A, Sutow WW.Extrarenal Wilms’ tumor. J Pediatr 1978; 93:439-43.
[9]	Constanzi G, Massarelli G, Bosincu L.Suun tumore embrionario dell’utero edegli annessi. Wilms extra-renale ouna nuova neoplasia. Anatomia 1970; 44:27-38.
[10]	Bittencourt AL, Britto JF, Fonseca LE Jr.Wilms' tumor of the uterus: the first report of the literature. Cancer 1981; 47: 2496-9.
[11]	Bell DA, Shimm DS, Gang DL.Wilms' tumor of the endocervix. Arch Pathol Lab Med 1985; 109: 371-3.
[12]	Comerci JT Jr, Denehy T, Gregori CA, Breen JL.Wilms' tumor of the uterus. A case report. J Reprod Med 1993; 38: 829-32.
[13]	Benatar B, Wright C, Freinkel AL, Cooper K.Primary extrarenal Wilms' tumor of the uterus presenting as a cervical polyp. Int J Gynecol Pathol 1998; 17: 277-80. doi: 10.1097/00004347-199807000-00014.
[14]	Jiskoot P, Aertsens W, Degels MA, Moerman P.Extrarenal Wilms' tumor of the uterus. Eur J Gynaecol Oncol 1999; 20: 195-7.
[15]	Iraniha S, Shen V, Kruppe CN, Downey EC.Uterine cervical extrarenal Wilms tumor managed without hysterectomy. J Pediatr Hematol Oncol 1999; 21: 548-50. doi: 10.1097/00043426-199911000-00020.
[16]	Babin EA, Davis JR, Hatch KD, Hallum Ⅲ AV.Wilms' tumor of the cervix: a case report and review of the literature. Gynecol Oncol 2000; 76: 107-11. doi: 10.1006/gyno.1999.5625.
[17]	Muc RS, Grayson W, Grobbelaar JJ.Adult extrarenal Wilms tumor occurring in the uterus. Arch Pathol Lab Med 2001; 125: 1081-3.
[18]	McAlpine J, Azodi M, O'Malley D, Kelly M, Golenewsky G, Martel M, et al. Extrarenal Wilms' tumor of the uterine corpus. Gynecol Oncol 2005; 96: 892-6. doi: 10.1016/j.ygyno.2004.11.029.
[19]	Leblebici C, Behzatoğlu K, Yildiz P, Koçyildiz Z, Bozkurt S.Extrarenal Wilms' tumor of the uterus with ovarian dermoid cyst. Eur J Obstet Gynecol Reprod Biol 2009; 144: 94-5. doi: 10.1016/j.ejogrb.2008.12.021.
[20]	García-Galvis OF, Stolnicu S, Muñoz E, Aneiros-Fernández J, Alaggio R, Nogales FF.Adult extrarenal Wilms tumor of the uterus with teratoid features. Hum Pathol 2009; 40: 418-24. doi: 10.1016/j.humpath.2008.05.020.
[21]	Song JS, Kim IK, Kim YM, Khang SK, Kim KR, Lee Y.Extrarenal teratoid Wilms' tumor: two cases in unusual locations, one associated with elevated serum AFP. Pathol Int 2010; 60: 35-41. doi: 10.1111/j.1440-1827.2009.02468.x.
[22]	Oner U U, Tokar B, Açikalin MF, Ilhan H, Tel N.Wilms' tumor of the ovary: A case report. J Pediatr Surg 2002; 37: 127-9. doi: 10.1053/jpsu.2002.29447.
[23]	Pereira F, Carrascal E, Cañas C, Flórez L.Extrarenal Wilms tumor of the left ovary: a case report. J Pediatr Hematol Oncol 2000; 22: 88-9. doi: 10.1097/00043426-200001000-00019.
[24]	Isaac MA, Vijayalakshmi S, Madhu CS, Bosincu L, Nogales FF.Pure cystic nephroblastoma of the ovary with a review of extrarenal Wilms' tumors. Hum Pathol 2000; 31: 761-4. doi: 10.1053/hupa.2000.7627.
[25]	Sahin A, Benda JA.Primary ovarian Wilms' tumor. Cancer 1988; 61: 1460-3.
[26]	Li L, Zhou XH, Deng YJ, Zhang HH, Ding YQ. A case report of Extra-renal Wilms’ tumor in the ovary of an adult patient. Chin J Pathol 2008; 37: 284-5. doi: 10.3321/j.issn:0529-5807.2008.04.020.
[27]	Gürsoy R, Akyol G, Tiras B, Güner H, Sahin I, Kurşaklioğlu S, et al.Adult extrarenal Wilms' tumor. A case report. Gynecol Obstet Invest 1995; 40: 141-4.
[28]	Ellison DA, Parham DM, Bridge J, Beckwith JB.Immunohistochemistry of primary malignant neuroepithelial tumors of the kidney: a potential source of confusion? A study of 30 cases from the National Wilms Tumor Study Pathology Center. Hum Pathol 2007; 38:205-11. doi: 10.1016/j.humpath.2006.08.026.
[29]	Arkovitz MS, Ginsburg HB, Eidelman J, Greco MA, Rauson A.Primary extrarenal Wilms’ tumor in the inguinal canal: case report and review of the literature. J Pediatr Surg 1996; 31: 957-9. doi: 10.1016/s0022-3468(96)90421-2.
[30]	Nogales FF Jr, Ortega I, Rivera F, Armas JR.Metanephrogenic tissue in immature ovarian teratoma. Am J Surg Pathol 1980; 4: 297-9. doi: 10.1097/00000478-198006000-00013.
[31]	Coppes MJ, Wilson PC, Weitzman S.Extrarenal Wilms' tumor: staging, treatment, and prognosis. J Clin Oncol, 1991, 9: 167-74. doi: 10.1200/JCO.1991.9.1.167.

Author publish year	Age (y/d)	Presenting symptoms	Tumor charac-teristics	Treatments	Chemotherapeutic regimens	Follow-up	Recurrence
Sahin et al²⁵ 1988	56	Bilateral calf pain, pelvic mass	12cm×11cm×7cm, solid ovoid mass	TAH, BSO, XRT, chemotherapy	Vincristine, dactinomycin, and cyclophosphamide	9 years	NED
Pereira et al²³ 2000	3.5	Abdominal pain, distension	13cm×10cm× 10cm lobulated mass confined to the right ovary	Right oophorectomy, chemotherapy	Vincristine and actinomycin D	6.5 years	NED
Isaac et al²⁴ 2000	21	Menorrhagia, abd-ominal symptoms, palpable pelvic mass	Right orarian mul- tilocular mass, in diameter of 19 cm	RSO, wedge resection of the left ovary, che- motherapy	Bleomycin, etoposide, cisplatin, vincristine and actinomycin D	6 months	NED
Oner et al²² 2002	3.5	Abdominal pain and vomiting	13cm×10cm× 6.5cm tuboovarian mass	Debulking, LSO, appendectomy and partial omentectomy, chemotherapy	Vincristine and actinomycin D	7 months	NED
Li et al²⁶ 2008	22	Abdominal disten-tion, abdominal pain, fever	Ovarian cystic mass, 18cm×14cm×3cm	Not stated	Not stated	Not stated	Not stated

Early edition

Current issue

Archive

Specialties & Topics

Author center

Reviewer center

Extrarenal Wilms’ Tumor of the Female Genital System: A Case Report and Literature Review^△

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 2

References 31

Related Articles 15

Metrics

Recommended 7

[1]	Liang Wang, Gang Li, Yun-tao Bing, Mao-lin Tian, Hangyan Wang, Chunhui Yuan, Dianrong Xiu. Does Prior Cancer Have an Influence on the Survival Outcomes of Patients with Localized Pancreatic Neuroendocrine Tumors? [J]. Chinese Medical Sciences Journal, 2021, 36(4): 284-294.
[2]	Gang Li, Yuntao Bing, Maolin Tian, Chunhui Yuan, Dianrong Xiu. Using a Nomogram to Preoperatively Predict Distant Metastasis of Pancreatic Neuroendocrine Tumor in Elderly Patients [J]. Chinese Medical Sciences Journal, 2021, 36(3): 218-224.
[3]	Jie Lv,Jie Yuan,Chaojian Xu,Jiaqi Hao,Yichuan Qin,Xiaoqiang Wang,Yongfeng Wang. VEGF-C/VEGFR-3/iNOS Signaling in Osteosarcoma MG63 Cells Mediates Stimulatory Effects on Human Umbilical Vein Endothelial Cell Proliferation [J]. Chinese Medical Sciences Journal, 2021, 36(1): 35-42.
[4]	Ju Liu,Zhijian Xu,Xiaofeng Bi,Ping Sun,Jiaqin Huang. Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors: A Retrospective Study [J]. Chinese Medical Sciences Journal, 2021, 36(1): 27-34.
[5]	Huang Chao, Xiang Keming, Liang Bingjun, Huang Weixuan, Zhang Fanjun, Shao Yuwan, Wang Xiulian, Liu Haosheng, Shen Weizeng. Combination of Evodiamine with Berberine Reveals a Regulatory Effect on the Phenotypic Transition of Colon Epithelial Cells Induced by CCD-18Co [J]. Chinese Medical Sciences Journal, 2020, 35(3): 195-206.
[6]	Zhang Aoli,Chen Xiaojuan,Li Zhanqi,Zhu Xiaofan. Primitive Neuroectodermal Tumor as the Second Malignant Neoplasm in a Long-Term Survivor Child of Acute Lymphoblastic Leukemia: A Case Report [J]. Chinese Medical Sciences Journal, 2020, 35(2): 186-190.
[7]	Wang Yingwei, Zhang Xinghua, Wang Botao, Wang Ye, Liu Mengqi, Wang Haiyi, Ye Huiyi, Chen Zhiye. Value of Texture Analysis of Intravoxel Incoherent Motion Parameters in Differential Diagnosis of Pancreatic Neuroendocrine Tumor and Pancreatic Adenocarcinoma [J]. Chinese Medical Sciences Journal, 2019, 34(1): 1-9.
[8]	Wang Botao, Fan Wenping, Xu Huan, Li Lihui, Zhang Xiaohuan, Wang Kun, Liu Mengqi, You Junhao, Chen Zhiye. Value of Magnetic Resonance Imaging Texture Analysis in the Differential Diagnosis of Benign and Malignant Breast Tumors [J]. Chinese Medical Sciences Journal, 2019, 34(1): 33-37.
[9]	Chen Xing,Wang Jianfeng,Ding Zhenshan,Zhou Xiaofeng. Solitary Fibrous Tumor of the Kidney Treated with Laparoscopic Partial Nephrectomy: A Case Report [J]. Chinese Medical Sciences Journal, 2018, 33(1): 64-68.
[10]	Li Xiao-feng, Liu Jian-zhou, Zhang Chao-ji, Miao Qi. Unicentric Castleman’s Disease with Cardiovascular Involvement [J]. Chinese Medical Sciences Journal, 2017, 32(3): 198-200.
[11]	Zhi-qiang Wang, Zhi-gang Wang, Pan Li, Hong-bing Cai. Endometrial Carcinoma Arising in Didelphic Uterus Accompanied by Right Renal Agenesis: A Case Report [J]. Chinese Medical Sciences Journal, 2016, 31(3): 200-202.
[12]	Cao Xi, Xie-qun Xu*, Tao Hong, Bing-lu Li, Wei Liu. Extrathyroidal Implantation of Thyroid Hyperplastic/neoplastic Cells after Endoscopic Thyroid Surgery [J]. Chinese Medical Sciences Journal, 2014, 29(3): 180-184.
[13]	Le-min Xia, Yi-yang Zhou. rmhTNF-α Combined with Cisplatin Inhibits Proliferation of A549 Cell Line In Vitro [J]. Chinese Medical Sciences Journal, 2014, 29(3): 185-187.
[14]	Wei Ma, Wen Tian*. Tumor Susceptibility in Proteus Syndrome: a Case Report [J]. Chinese Medical Sciences Journal, 2014, 29(2): 120-121.
[15]	Ming-chao Fan, Peng Sun, Dong-liang Lin, Yi Yu, Wei-cheng Yao, Yu-gong Feng, Li-min Tang. Primary Endodermal Sinus Tumor in the Posterior Cranial Fossa: Clinical Analysis of 7 Cases [J]. Chinese Medical Sciences Journal, 2013, 28(4): 225-228.

Extrarenal Wilms’ Tumor of the Female Genital System: A Case Report and Literature Review△