Chinese Medical Sciences Journal ›› 2021, Vol. 36 ›› Issue (2): 110-119.doi: 10.24920/003794
• Original Article • Previous Articles Next Articles
Assessing Liver Function by T1 Maps on Gd-EOB-DTPA-Enhanced MRI for up to 50 Min in Rat Models of Liver Fibrosis: A Longer Hepatobiliary Time Period may Help
Jia Xu1, Xuan Wang1, *(
), Zhengyu Jin1, *(), Qin Wang1, Yan You2, Shitian Wang1, Tianyi Qian3, Huadan Xue1
- 1Department of Radiology,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
3Siemens Healthcare Ltd., Beijing 100102, China
-
Received:2020-09-15Published:2021-06-30 -
Contact:Xuan Wang,Zhengyu Jin E-mail:dr_wangxuan@163.com;jinzy@pumch.cn
| The authors used longer time period of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid-enhanced MRI to investigate liver function of carbon tetrachloride-induced hepatic injury rat models. The results indicated a longer time period of T1 mapping scanning had the potential to provide information about liver function of rats with liver fibrosis. |
Cite this article
Jia Xu, Xuan Wang, Zhengyu Jin, Qin Wang, Yan You, Shitian Wang, Tianyi Qian, Huadan Xue. Assessing Liver Function by T1 Maps on Gd-EOB-DTPA-Enhanced MRI for up to 50 Min in Rat Models of Liver Fibrosis: A Longer Hepatobiliary Time Period may Help[J].Chinese Medical Sciences Journal, 2021, 36(2): 110-119.
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Figure 1.
Magnetic resonance imaging (MRI) protocol and image analysis. The MRI protocol included dynamic contrast enhanced (DCE) sequence, multiple hepatobiliary phase acquisitions, and T1 mapping series. The regions of interest were drawn and the MRI parameters were measured and calculated from different datasets include: 1) T1 relaxation time, T1 reduction rate (ΔT1) at different time points, and the elimination half-life of ΔT1 (TΔT1 1/2); 2) Relative enhancement (RE) at 3, 20, and 50 min, TRE1/2, Tmax, and REmax; 3) extravascular volume transfer (Ktrans), extravascular fluid volume (Ve), extravascular to plasma volume transfer (Kep), and initial area under the enhancement curve (iAUC). "
Figure 1.
Figure 2.
Pathological micrographs of rats in the control group and experimental group. Histopathological analysis of liver sections stained with Masson trichrome (×100) showing normal (A) and liver fibrosis with CCl4 exposure (B). "
Figure 2.
Figure 3.
The T1 value-time curve (A), T1 reduction rate-time curve (B), and T1 maps obtained before (C, E, G) and 50 min after Gd-EOB-DPTA administration (D, F, H) of three rat models with varying liver function. The indocyanine green retention rate at 15 min (ICG R15) values of rat number 1, rat number 2, and rat number 3 was 4.4%, 15.5%, and 32.5%, respectively. The worse the liver function was, the smaller T1 value and larger T1 reduction rate were found in the late hepatobiliary phase."
Figure 3.
Figure 4.
Scattergrams showing the relationships between the T1 mapping parameters, relative enhancement parameters, and indocyanine green retention rate at 15 minutes (ICG R15). T1 relaxation time at 50 min showed a significant negative correlation with ICG R15 (A, r=-0.634, P=0.049). ΔT1 30min, ΔT1 40min, ΔT1 50min showed significant positive correlations with ICG R15 (B, r=0.784, P=0.007; C, r=0.653, P=0.041; and D, r=0.757, P=0.030, respectively). TΔT1 1/2 showed a significant positive correlation with ICG R15 (E, r=0.685, P=0.029). TRE1/2 and Tmax showed significant positive correlation with ICG R15 (F, r=0.535, P=0.018; G, r=0.532, P=0.019). "
Figure 4.
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