Chinese Medical Sciences Journal ›› 2012, Vol. 27 ›› Issue (4): 249-252.doi: 10.1016/S1001-9294(13)60010-3

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A Small Solitary Pulmonary Nodule Discovered by 18F-fluorodeoxyglucose Positron Emission Tomography and CT: Rare Infection Instead of Rare Tumor

Da-ming Zhang1, Hua-dan Xue1, Lian Duan23, Ji Li4, Nai-shi Li23, Zheng-yu in1*   

  1. 1Department of Radiology; 2Department of Endocrinology; 3Key Laboratory of Endocrinology of Ministry of Health; 4Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  • Received:2012-11-05 Published:2013-01-07 Online:2013-01-07
  • Contact: *Corresponding author Tel: 86-10-69155442, E-mail: jin_zhengyu@ E-mail:jin_zhengyu@
  • About author:*Corresponding author Tel: 86-10-69155442, E-mail: jin_zhengyu@

THE causes of Cushing′s syndrome are mainly divided into adrenocorticotropic hormone (ACTH) dependent and independent. ACTH dependent hypercortisolism represents excess ACTH se-creting by the pituitary or tumor outside the pituitary; and the latter one is also called as ectopic ACTH syndrome. Thorax is the most common location of causative lesions for ectopic ACTH syndrome, and the size of lesion is too small to be detected in some cases.1, 2 Cryptococcal pneumonia usually occurs in immunocompromised patients and excess cortisol production can theoretically produce a state of immunodeficiency. Development of cryptococcal pneumonia concomitant with Cushing syndrome (CS) was rare. Here, we report a case of pulmonary nodule in a patient with CS differentiated with ectopic ACTH-producing tumor. Cryptococcal pneumonia was diagnosed following lung resection.

Key words: Cushing syndrome, pulmonary cryptococcosis, ectopic adrenocorticotropic hormone-producing tumor

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