Chinese Medical Sciences Journal ›› 2015, Vol. 30 ›› Issue (1): 44-50.doi: 10.1016/S1001-9294(15)30008-0

• ORIGINAL ARTICLE • Previous Articles     Next Articles

Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndrome: a Meta-analysis

Lei Qiu1, Jing Liu1, Qi-ming Hei2, *   

  1. 1 Department of Health Management,2 Department of Labor and Social Security, School of Management, Hainan Medical University, Haikou 570100, China
  • Online:2015-04-02 Published:2015-04-02
  • Contact: *Corresponding author Tel: 86-898-66891279, E-mail:1005727838@qq.com

Abstract: Objective To investigate the association between two polymorphisms of follicle stimulating hormone receptor (FSHR) gene and polycystic ovary syndrome (PCOS) susceptibility.
Methods Case-control studies on relationship of Thr307Ala and Asn680Ser polymorphisms in FSHR gene and PCOS susceptibility were searched from PubMed, ISI web of knowledge, EBSCO, and China National Knowledge Infrastructure (CNKI) databases up to March 21, 2013. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed- or random-effect model based on heterogeneity test in 5 genotype models analyses.
Results A total of 11 studies were included in the Meta-analysis. The random-effect analysis showed Asn680Ser was significantly associated with the reduced susceptibility to PCOS with dominant model (Asn/Asn+Asn/Ser vs. Ser/Ser, OR=0.83, 95% CI: 0.69-1.00), recessive model (Asn/Asn vs. Asn/Ser+ Ser/Ser, OR=0.84, 95% CI: 0.72-0.98), homozygote comparison (Asn/Asn vs. Ser/Ser, OR=0.79, 95% CI: 0.63-0.98), and the allele contrast (Asn vs. Ser, OR=0.87, 95% CI: 0.79-0.97) respectively(P=0.02, I2=56.0%), being protective factors for PCOS. However, no significant associations were found between Thr307Ala and PCOS.
Conclusion There might be a significant association between Asn680Ser polymorphism and PCOS.

Key words: follicle stimulating hormone receptor, polycystic ovary syndrome, Meta-analysis, single-nucleotide polymorphism

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