Chinese Medical Sciences Journal ›› 2020, Vol. 35 ›› Issue (4): 357-365.doi: 10.24920/003659
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Wnt5a Plays Controversial Roles in Cancer Progression
Xu Chen1, Hongling Liu2, Fenghui Zhao1, *(
), Zongxian Jiao3, Jinsui Wang1, Yamei Dang1
- 1Department of Pathology, Gansu Provincial Hospital, Lanzhou 730000, China
2Department of Occupational Medicine, the Third Gansu Provincial Hospital, Lanzhou 730000, China
3Pathological Institution of Basic Medical College, Lanzhou University, Lanzhou 730000, China
-
Received:2019-09-12Accepted:2020-02-04Published:2020-12-31Online:2020-10-28 -
Contact:Fenghui Zhao E-mail:zhaofh0931@163.com
Cite this article
Xu Chen, Hongling Liu, Fenghui Zhao, Zongxian Jiao, Jinsui Wang, Yamei Dang. Wnt5a Plays Controversial Roles in Cancer Progression[J].Chinese Medical Sciences Journal, 2020, 35(4): 357-365.
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Figure 1.
Wnt signaling pathway. The two groups of Wnt factors regulate the β-catenin, calcium and planar cell polarity (PCP)/convergent extension (CE) pathways. APC, adenomatous polyposis coli; CAMK Ⅱ, calmodulin dependent protein kinase Ⅱ; LRP, lipoprotein receptor-related protein co-receptor; DAG, diacylglycerol; Dvl, dishevelled; IP3, inositol 1,4,5-trisphosphate; JNK, Jun N-terminal kinase; NFAT, nuclear factor of activated T cell; PIP2, phosphatidylinositol 4,5-bisphosphate; PLC, proteins and phospholipase C; PKC, protein kinase C; Ror2, receptor tyrosine kinase-like orphan receptor 2; TCF, T-cell factor; LEF, lymphoid enhancer factor."
Figure 1.
Figure 2.
Ambiguous roles of Wnt5a in cancer metastasis. (A) Inhibition of metastasis in cancer. (B) Promotion of metastasis in cancer. ARF6, ADP-ribosylation factor 6; NF-kB, nuclear factor-kB; IL-10, interleukin 10; PI3K, phosphatidylinositol 3‐kinase; Siah2, absentia homologues 2; TLR-4, toll-like receptor-4."
Figure 2.
Figure 3.
WNT5A methyl modification might influence on Wnt5a controversial roles. Gene methylation might lead to distinct mRNA isoforms. Furthermore, WNT5A methyl modification influence on Wnt5a expression level and Wnt5a acts on different signal pathway."
Figure 3.
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