Genetic Basis of Gastric Cancer

doi:10.1016/S1001-9294(16)30050-5

Abstract

Gastric cancer is the result of multiple risk factors, including environmental factors, genetic factors and the interaction between them. The environmental factors mainly include dietary, Helicobacter pylori infection and family history of gastric cancer. Genetic factors mainly refer to the susceptible genes that cause epigenetic alterations in oncogenes, tumor suppress genes, cell cycle regulators, DNA repair genes and signaling molecules. This paper summarizes the susceptible genes of gastric cancer and explores the genetic basis of it.

Key words: gastric cancer, genetic factors

Yue-wen Gao, Chun-hua Zhang, Xing-mei Zuo, Xi-zeng Hui. Genetic Basis of Gastric Cancer[J].Chinese Medical Sciences Journal, 2016, 31(3): 192-195.

References 30

1	FujinoY, Tamakoshi A, Ohno Y, et al. Prospective study of educational background and stomach cancer in Japan. Prev Med 2002; 35:121-7.
2	Lazarevic K, Nagorni A, Rancic N, et al. Dietary factors and gastric cancer risk: hospital-based case control study. J Buon 2010; 15:89-93.
3	Nagini S. Carcinoma of the stomach: a review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol 2012; 4:156-69.
4	Wu XX, Li H, Zhao M. Medical Molecular Biology. Beijing: Science Press; 2009. p.303-4.
5	Kuniyasu H, Yasui W, Yokozaki H, et al. Aberrant expression of c-met mRNA in human gastric carcinomas. Int J Caneer 1993; 55:72-5.
6	Bao M, Wu JF. Expression of C-met in gastric carcinoma and its clinical significance. Anhui Med J 2012; 3:687-9．
7	Zhuang XQ, Lin SR, Zheng J, et al. Relationship between gastric lesions and c-met proto-oncogene expression and prognostic significance. Chin J Dig 2001; 21:116-7.
8	Ma GF, Cai HX, Ding FY, et al. Expression of c-Met in gastric cancer tissues and its clinical significance. Chin J Cancer Biother 2013; 20:603-8.
9	Motojima K, Furui J, Kohara N, et al. erbB-2 expression in well-differentiated adenocarcinoma of the stomach predicts shorter survival after curative resection. Surgery 1994; 115:349-54.
10	Yonemura Y, Ninomiya I, Yamagudil A, et al. Evaluation of immunoreactivity of erbB-2 protein as a marker of poor short term prognosis in gastric cancer. Cancer Res 1991; 51:1034-8.
11	Shai AR, Zhao JS, Shang P, et al. The expression of C-erb-B2 cathepsin-D and its clinical significance in gastric cancer. J Diag Pathol 2002; 9:290.
12	Mei D, Liu Y, Hu F, et al. Expression and clinical significance of C-erb-B2 and Ki67 in gastric carcinoma. Chin J Microecol 2015; 27:828-30．
13	Lei J, Wang Z, Zhang H, et al. Lipopolysaccharide induced apoptosis in a murine intestinal endocrine cell line by modulation of Bcl-2, Bax and caspase-3. Mol Med Rep 2013; 8:1649-54．
14	Gobe G, Rubin M, Williams G, et al. Apoptosis and expression of Bcl-2, Bcl-XL, and Bax in renal cell carcinomas. Cancer Invest 2002; 20:324-32．
15	Chou HK, Chen SL, Hsu CT, et al. Bcl-2 accelerates retinoic acid-induced growth arrest and recovery in human gastric cancer cells. Biochem J 2003; 348:473-9.
16	Kim R, Emi M, Tanabe K, et al. Therapeutic potential of antisense Bcl-2 as a chemosentisizer for cancer therapy. Cancer 2004; 101:2491-502.
17	Zhu YJ, Qiu M, Zhou JT. Analysis of the p53 transcriptional activity in gastric cancer. Chin J Med Gene 2010; 27:60-6.
18	Yokobori T, Mimori K, Iwatsuki M, et al. p53-altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res 2009; 69:3788-94.
19	Sirak I, Petera J, Hatlova J, et al. Expression of p53, p21 and p16 does not correlate with response to preoperative chemoradiation in gastric carcinoma. Hepatogastroenterology 2009; 56:1213-8.
20	Murakami K, Fujioka T, Kodama M, et al. Analysis of p53 mutations and Helicobacter pylori infection in human and animal models. Gastroenterol 2002; 37:1-5.
21	Grace A, Butler D, Gllagher M, et al. APC gene expression in gastric carcinorma: an immunohistochemical study. Appl Immunohistochem Mol Morphol 2002; 10:221-4.
22	Tamura G, Maesawa C, Suzuki Y, et al. Primary gastric carcinoma cells frequently lose heterozygosity at the APC and genetic loci. Jpn J Cancer Res 1993; 84:1015-8.
23	Wang JY, Hsieh JS, Chen CC, et al. Alterations of APC, c-met and P53 gene in tumor tissue and serum of patients with gastric cancers. J Surg Res 2004; 120:242-8.
24	Zhang Y, Zhai K, Jiang MJ, et al. The DCC mRNA expression and significance in gastric carcinoma. Shandong Med J 2015; 55:44-5.
25	Polvak K, Lee MH, Hediye EB, et al. Cloning of P27kipl, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular signals. Cell 1994; 78:59-66.
26	Toyoshima H, Hunter T. P27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to P21. Cell 1994; 78:67-74.
27	Cui Y, Zhang G, Li Z, et al. Role of p16 gene methylation in the pathogenesis of gastric cancer. J Clin Med Pract 2015; 19:49-51.
28	Wang M, Li Y, Gao J, et al. p16 methylation is associated with chemosensitivity to fluorouracil in patients with advanced gastric cancer. Med Oncol 2014; 31:988．
29	Sakellariou S, Liakakos T, Ghiconti I, et al. Immunohistochemical expression of P15 (INK4B) and SMAD4 in advanced gastric cancer. Anticancer Res 2008; 28:1079-83.
30	Cito L, Pentimalli F, Forte I, et al. Rb family proteins in gastric cancer. Oncol Rep 2010; 24:1411-8.

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