Chinese Medical Sciences Journal ›› 2016, Vol. 31 ›› Issue (3): 192-195.doi: 10.1016/S1001-9294(16)30050-5

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Genetic Basis of Gastric Cancer

Yue-wen Gao, Chun-hua Zhang, Xing-mei Zuo, Xi-zeng Hui*   

  1. Department of Surgery, Rizhao People’s Hospital, Rizhao, Shandong 276828, China
  • Published:2016-09-20 Online:2016-09-20
  • Contact: Tel: 86-18606330932, E-mail:

Gastric cancer is the result of multiple risk factors, including environmental factors, genetic factors and the interaction between them. The environmental factors mainly include dietary, Helicobacter pylori infection and family history of gastric cancer. Genetic factors mainly refer to the susceptible genes that cause epigenetic alterations in oncogenes, tumor suppress genes, cell cycle regulators, DNA repair genes and signaling molecules. This paper summarizes the susceptible genes of gastric cancer and explores the genetic basis of it.

Key words: gastric cancer, genetic factors

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