Chinese Medical Sciences Journal ›› 2021, Vol. 36 ›› Issue (2): 135-149.doi: 10.24920/003729

• Review • Previous Articles     Next Articles

Potential Biomolecules Capable of Assessing Risk of Osteoporotic Fracture: A Scoping Review

Jieyu Liu1, 2, 3, Jiaxiang Wang1, 2, 3, Li Xu1, 2, Feiyan Deng1, 2, *()   

  1. 1Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China
    2Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China
    3Department of Epidemiology and Biostatics, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China
  • Received:2020-09-13 Published:2021-06-30 Online:2021-07-07
  • Contact: Feiyan Deng E-mail:fdeng@suda.edu.cn

Osteoporosis as a systemic chronic skeletal disease is characterized by low bone mineral density and increased risk to osteoporotic fractures. Osteoporosis is prevalent in the middle-aged and elderly population, especially in the postmenopausal women. With population aging, osteoporosis has become a world-wide serious public health problem. Early recognition of the high-risk population followed by timely and efficient intervention and/or treatment is important for preventing osteoporotic fractures. In light of the high heritability and complex pathogenesis of osteoporosis, comprehensive consideration of vital biological/biochemical factors is necessary for accurate risk evaluation of fractures. For this purpose, we review recent research progress on molecules which can be applied to assess risk for osteoporotic fractures. Future integrative analyses and systematic evaluation of these molecules may facilitate developing novel methodologies and/or test strategies, i.e., biochips, for early recognition of osteoporosis, hence contributing to preventing osteoporotic fractures.

Key words: osteoporotic fracture, molecules, predictive, diagnostic

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