Chinese Medical Sciences Journal ›› 2017, Vol. 32 ›› Issue (2): 123-128.doi: 10.24920/J1001-9294.2017.016
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Trigeminal Ganglioneuroma in the Middle-posterior Cranial Fossa: a Case Report△
Wang Ting1, Ma Lin1, Lou Xin1, Bu Bo2, *(
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- 1Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China
2Department of neurosurgery, Chinese PLA General Hospital, Beijing 100853, China
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Received:2016-06-06Published:2017-06-30Online:2017-06-10 -
Contact:Bu Bo E-mail:surgeon301@126.com
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Wang Ting, Ma Lin, Lou Xin, Bu Bo. Trigeminal Ganglioneuroma in the Middle-posterior Cranial Fossa: a Case Report△[J].Chinese Medical Sciences Journal, 2017, 32(2): 123-128.
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Figure 1.
Images of cranial CT scan and postoperative MRI.A. A heterogeneous low-density mass in size of 4.2cm×5.2cm in the right middle-posterior cranial fossa with dotty calcification inside. B. Bone window image showed absorption and thinning of the sphenoid and ethmoid bone. C. Postoperative CT image demonstrated complete resection of the tumor. D-F. Postoperative MRI images (T2WI,T1WI, and enhanced T1WI) five months after the operation showed the tumor was resected completely with no residue and recurrence."
Figure 1.
Figure 2.
MRI findings on pre- and post-contrast MRI and diffusion-weighted imaging before operation. A. Axial T2WI image and B. Axial T1WI image showed a well-defined mass with heterogeneous signal intensity in the right middle-posterior cranial fossa. C. Remarkable heterogeneous enhancement on contrast enhanced axial T1WI. D. Coronal contrast enhanced T1WI image showed the lesion surround the right internal jugular vein. E. Diffusion-weighed imaging (b=1000 s/mm2) revealed a hypointensity tumor. F. Apparent diffusion coefficient mapping showed relatively hyperintensity of the tumor."
Figure 2.
Figure 3.
Photographs of intra-operative findings. A. After the focal skull removed, the dura was exposed and extradural tumor was identifiable. B. Cystic component of the intratumoral cavity (asterisk). Maxillary and mandibular nerve were well reserved while the tumor was resected completely. V2, maxillary nerve; V3, mandibular nerve; T, tumor."
Figure 3.
Figure 4.
Histological findings of ganglioneuroma. A. Mixture of large ganglion cells (arrows) and spindle-shaped Schwann-like cells (H&E staining, 400×). B. Dysplastic ganglion cell with binucleated cell (arrow) (H&E staining, 400×). C. Calcification (arrow) and hyaline degeneration (asterisk) in tumor (H&E staining, 100×). D. S-100 positive cells accompanied with giant ganglion cells (arrows) supporting the neurogenic nature of the tumor (S-100 protein immunohistochemical staining, 400×). E. CD34 positive cells presented in blood vessels, indicating angiogenesis of the tumor (CD34 immunohistochemical staining, 400×). F. 3% Ki-67 positive cells confirmed the benign neoplasm (arrows) (Ki-67 immunohistochemical staining, 400×)."
Figure 4.
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