特发性膜性肾病患者血栓栓塞事件发病率及危险因素的队列研究

邹佩美,李航,蔡建芳,陈振杰,李超,徐平,李明喜,陈丽萌,李雪梅,李学旺

A Cohort Study of Incidences and Risk Factors for Thromboembolic Events in Patients with Idiopathic Membranous Nephropathy

Zou Peimei,Li Hang,Cai Jianfang,Chen Zhenjie,Li Chao,Xu Ping,Li Mingxi,Chen Limeng,Li Xuemei,Li Xuewang

Table 2 Comparison of the clinical characteristics at the time of events between ATEs and VTEs§

Characteristics ATEs (n=58) VTEs (n=56) P value? Mean/ Median Early onset (n=27) Delayed onset (n=31) P value* Mean/ Median Early onset (n=48) Delayed onset (n=8) P value* Age, year 59.0±11.4 59.4±11.8 58.7±11.2 0.81 50.0±15.4 49.0±16.0 56.4±9.5 0.21 0.001 Proteinuria, g/24 h 3.5(1.05, 7.12) 4.5(2.0, 6.7) 2.8(0.7, 7.8) 0.33 6.2(4.5, 9.6) 6.2(4.5, 9.8) 6.7(4.4, 9.2) 0.76 0.002 Serum albumin, g/L 29.8±8.0 26.8±7.6 32.4±7.5 0.01 25.1±7.7 25.1±8.1 25.1±5.8 1.00 0.002 eGFR, ml/min/ 1.73m2 84.2±22.1 87.5±20.8 81.6±23.1 0.35 94.8±22.3 96.6±21.4 84.0±26.3 0.14 0.02 Total cholesterol, mmol/L 7.4(5.1, 8.9) 7.8(6.5, 8.9) 6.1(4.9, 9.3) 0.11 8.0(6.3, 9.3) 8.4±2.7 7.9±1.4 0.66 0.21 Triglycerides, mmol/L 2.1(1.7, 3.0) 2.1(1.7, 4.3) 2.6(1.1, 2.9) 0.75 3.4(1.9, 4.4) 3.4(2.0, 4.0) 1.9(1.6, 4.8) 0.63 0.04 LDL-C, mmol/L 4.3(2.7, 6.5) 5.5(2.7, 6.7) 3.8(2.6, 6.4) 0.27 4.5(3.4, 7.0) 4.5(3.3, 7.2) 4.51(3.45, -) 0.87 0.54 NS, n (%) < 0.001 NS status 24 (42.1) 16 (59.3) 8 (26.7) 0.01 44 (81.5) 38 (79.2) 6 (75.0) N/A Sub-NS 22 (38.6) 10 (37.0) 12 (38.7) 8 (14.8) 8 (16.7) 0 (0.0) CR 11 (19.3) 1 (3.7) 10 (35.5) 2 (3.7) 2 (4.2) 0 (0.0)