特发性膜性肾病患者血栓栓塞事件发病率及危险因素的队列研究

邹佩美,李航,蔡建芳,陈振杰,李超,徐平,李明喜,陈丽萌,李雪梅,李学旺

A Cohort Study of Incidences and Risk Factors for Thromboembolic Events in Patients with Idiopathic Membranous Nephropathy

Zou Peimei,Li Hang,Cai Jianfang,Chen Zhenjie,Li Chao,Xu Ping,Li Mingxi,Chen Limeng,Li Xuemei,Li Xuewang

Table 3 Univariable model proportional-hazards analysis on association of clinical characteristics with VTE and ATE

Variables n ATE VTE HR 95% CI Pvalue HR 95% CI P value Sex, male 449 1.2 0.8-2.0 0.39 1.6 0.8-2.4 0.29 Age, years 766 < 0.001 0.35 <35 167 1.0 reference 1.0 reference 35-54 323 5.1 1.2-21.7 0.8 0.4-1.7 ≥55 276 13.0 3.1-53.3 1.3 0.6-2.6 History of 766 Smoking 228 1.7 1.0-2.7 0.03 0.9 0.5-1.7 0.81 Hypertension 360 1.8 1.1-3.0 0.02 0.9 0.5-1.6 0.77 Diabetes 90 1.5 0.8-2.8 0.24 1.3 0.6-2.9 0.44 ATE 35 2.4 1.1-5.2 0.03 0.8 0.2-3.4 0.79 Proteinuria, g/24 h 712 0.04 0.03 <3.5 191 1.0 reference 1.0 reference 3.5-8.0 313 1.3 0.7-2.7 3.6 1.3-10.5 >8.0 208 2.2 1.1-4.4 4.3 1.5-12.8 Serum albumin, g/L 710 0.64 0.01 <20 73 1.6 0.6-4.4 5.5 1.5-19.9 20-35 198 1.4 0.6-3.0 2.3 0.7-7.6 ≥35 246 1.0 reference 1.0 reference eGFR, ml/min/1.73 m2 760 0.10 0.27 ≥90 517 1.0 reference 1.0 reference 60-89 195 1.4 0.8-2.4 1.4 0.8-2.5 <60 48 2.2 1.0-4.8 0.3 0.1-2.4 Total cholesterol, mmol/L 543 0.97 0.14 <5.18 43 1.0 reference 1.0 reference 5.18-7.76 240 0.9 0.3-2.4 2.4 0.3-18.3 >7.76 260 0.9 0.3-2.3 4.1 0.6-30.5