PD-1/PD-L1调控及其在肿瘤靶向治疗的前景展望

倪杰明,倪安平

Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy

Ni Jieming,Ni Anping

Figure 1. The regulation network of PD-1/PD-L1. PI3K/Akt/mTOR and MAPK signal pathway induces PD-1/PD-L1 expression, and transcriptional factors HIF, PTEN, p53, CDK5, BRD4, STAT etc modulate PD-1/PD-L1 expression. PD-1/PD-L1 level is also regulated via epigenetical and post-translational manner. GSK: glycogen synthase kinase; HRE: hypoxia response element; MMP: matrix metalloprotein.