妊娠引起的噬血细胞性淋巴组织细胞增生症：病例报告与文献回顾

赵杰,杨翼萌,明树红

Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review

Jie Zhao,Yimeng Yang,Shuhong Ming

Table 2 Cases of HLH during pregnancy reported in the literature

No. Reference Maternal age (years) Gestation (weeks) Associated disease Treatment Maternal outcome Fetal outcome 1 Nakabayashi et al., 1999[8] 30 21 Preeclampsia Antithrombin survive survive 2 Chmait et al., 2000[9] 24 29 Necrotizing lymphadenitis, EBV Ampicillin, acyclovir Betamethasone, IgG death survive 3 Hanaoka et al., 2007[10] 33 21 B-cell lymphoma Emergent caesarean section ; R-CHOP chemotherapy survive survive 4 Teng et al., 2009[11] 28 23 Autoimmune haemolytic anaemia No response to corticosteroid; caesarean section survive death 5 Arewa et al., 2011[12] 31 21 HIV HAART survive survive 6 Shukla et al., 2013[13] 23 10 NS No response to prednisolone; spontaneous abortion survive death 7 Goulding et al., 2014[14] 27 23 HSV-2 Acyclovir survive death 8 Mayama et al., 2014[15] 28 20 Parvovirus B19 Prednisolone survive survive 9 Klein et al., 2014[16] 39 30 EBV Corticosteroid, cyclosporine A, etoposide, Rituximab death survive 10 Tumian et al., 2015[17] 35 38 CMV Dexamethasone death survive 11 Giard et al., 2016[18] 35 13 Streptococcal pharyngitis, KF lymphadenitis No response to corticosteroids; dexamethasone and etoposide; abortion death death 12 Rousselin et al., 2017[19] 44 30 Raynaud syndrome, thrombocytopenia Antimicrobial therapy, glucocorticosteroids survive survive 13 He et al., 2017[20] 27 30 NK/T cells lymphoma Dexamethasone, rituximab and etoposide death survive 14 Ikeda et al., 2017[21] 36 11 EBV Dexamethasone, cyclosporine, Etoposide survive survive 15 Yildiz et al., 2018[22] 36 NS Acute hepatitis, HIV Metronidazole, ceftriaxone, methylprednisolone, antibiotherapy survive survive 16 Wang et al., 2018[23] 40 NS UNC13D gene mutation Etoposide, dexamethasone survive death 17 Nasser et al., 2018[7] 36 31 HSV-2 Acyclovir survive death 18 Neistadt et al., 2018[24] NS 27 NK/T-cell lymphoma Corticosteroids, etoposide, pembrolizumab death death 19 Parrott et al., 2019[25] 28 18 Lupus No response to etoposide and corticosteroid death death