PRE-EXPOSURE OF MICE TO LOW DOSE OR LOW DOSE RATE IONIZING RADIATION REDUCES  CHROMOSOME ABERRATIONS INDUCED BY SUBSEQUENT EXPOSURE TO HIGH DOSE OF RADIATION OR MITOMYCIN C

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PRE-EXPOSURE OF MICE TO LOW DOSE OR LOW DOSE RATE IONIZING RADIATION REDUCES CHROMOSOME ABERRATIONS INDUCED BY SUBSEQUENT EXPOSURE TO HIGH DOSE OF RADIATION OR MITOMYCIN C

Chinese Medical Sciences Journal Issue 1, (1995)

Updated：2024-04-10

- PRE-EXPOSURE OF MICE TO LOW DOSE OR LOW DOSE RATE IONIZING RADIATION REDUCES CHROMOSOME ABERRATIONS INDUCED BY SUBSEQUENT EXPOSURE TO HIGH DOSE OF RADIATION OR MITOMYCIN C
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  CLC： R363
- Published：1995
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[1]于文儒,王明东,蔡露,金玉珂.PRE-EXPOSURE OF MICE TO LOW DOSE OR LOW DOSE RATE IONIZING RADIATION REDUCES[J].Chinese Medical Sciences Journal,1995(01):50-53.

PRE-EXPOSURE OF MICE TO LOW DOSE OR LOW DOSE RATE IONIZING RADIATION REDUCES CHROMOSOME ABERRATIONS INDUCED BY SUBSEQUENT EXPOSURE TO HIGH DOSE OF RADIATION OR MITOMYCIN C[J]. Chinese medical sciences journal, 1995, (1).
[1]于文儒,王明东,蔡露,金玉珂.PRE-EXPOSURE OF MICE TO LOW DOSE OR LOW DOSE RATE IONIZING RADIATION REDUCES[J].Chinese Medical Sciences Journal,1995(01):50-53. DOI：

PRE-EXPOSURE OF MICE TO LOW DOSE OR LOW DOSE RATE IONIZING RADIATION REDUCES CHROMOSOME ABERRATIONS INDUCED BY SUBSEQUENT EXPOSURE TO HIGH DOSE OF RADIATION OR MITOMYCIN C[J]. Chinese medical sciences journal, 1995, (1). DOI：

摘要

ＰＲＥ－ＥＸＰＯＳＵＲＥＯＦＭＩＣＥＴＯＬＯＷＤＯＳＥＯＲＬＯＷＤＯＳＥＲＡＴＥＩＯＮＩＺＩＮＧＲＡＤＩＡＴＩＯＮＲＥＤＵＣＥＳＣＨＲＯＭＯＳＯＭＥＡＢＥＲＲＡＴＩＯＮＳＩＮＤＵＣＥＤＢＹＳＵＢＳＥＱＵＥＮＴＥＸＰＯＳＵＲＥＴＯＨＩＧＨＤＯＳＥＯＦＲ...

Abstract

The phenomenon of cytogenetic adaptive and cross-adaptive response induced by low dose irradiation and chemical mutagen in mice is described. We found

firstly

that adaptation can be induced by acute low dose Xirradiation （0-100 mGy）. Secondly

a cross-adaptation can occur between X-irradiation and mitomycin C （MMC）. And finally

mice pre-exposed to chronic low dose rate￣（60）Co-Gamma irradiation （0-226.0 mGy/day） are less susceptible to chromosome aberration induced by subsequent acute higher Xirradiation. Therefore

our data suggest that radioadaptive response depends on dose

dose rate and time interval. Possible mechanisms are also discussed.

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