Blue Nevus Hidden within the Nevus of Ota

Xing Liu; Hui-Ying Zheng; Fu-Min Fang; He-Dan Yang; Hui Ding; Yin Yang; Yi-Ping Ge; Tong Lin

doi:10.24920/004092

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Blue Nevus Hidden within the Nevus of Ota

Chinese Medical Sciences Journal Vol. 38, Issue 1, Pages: 70-72(2023)

Case Report | Updated：2024-03-30

- Blue Nevus Hidden within the Nevus of Ota
- Affiliations：
  
  1. 1Department of Cosmetic Laser Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
  2. 2Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
- Author bio：
  
  Yiping Ge, gypfeng@hotmail.com
  *Tong Lin, ddlin@hotmail.com;
- Funds：
- DOI：10.24920/004092
  CLC：
- Received：02 April 2022，
  
  Accepted：2022-7-28，
  
  Published Online：24 February 2023，
  
  Published：31 March 2023
- Accepted：
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Xing Liu, Hui-Ying Zheng, Fu-Min Fang, et al. Blue Nevus Hidden within the Nevus of Ota[J]. Chinese medical sciences journal, 2023, 38(1): 70-72.
DOI：

Xing Liu, Hui-Ying Zheng, Fu-Min Fang, et al. Blue Nevus Hidden within the Nevus of Ota[J]. Chinese medical sciences journal, 2023, 38(1): 70-72. DOI： 10.24920/004092.

摘要

太田痣是一种良性的、色素增多性皮肤病，皮损好发于面部，一般表现为单侧褐色至蓝色斑片。虽然该病通常情况下是良性的，但可能合并其他色素增多性疾病甚至恶变为黑素瘤。我们报道一例3岁男孩在左脸出现蓝色斑片和分散分布的蓝色斑点，经过几次激光治疗后，眼眶周围的蓝色斑块颜色逐渐加深，组织病理检查发现真皮可见多数双极树突状细胞，胞浆内含有色素颗粒，组化结果为S100(+)，SOX-10(+)，Melan-A(+)，P16(+)，HMB-45(+)，Ki-67<5%。最后，诊断为太田痣合并蓝痣。因此，对于激光治疗效果不佳的太田痣，应怀疑可能同时存在其他疾病，需要进一步随访。

Abstract

A 3-year-old boy presented with bluish patch and scattered blue spots on the left side of his face. After several sessions of laser treatment

the azury patch in the periorbital area became even darker. Histopathology showed many bipolar

pigment-laden dendritic cells scattered in the papillary and upper reticular dermis. Immunohistochemically

these cells were positive for S100

SOX-10

melan-A

P16

and HMB-45. The positive rate of Ki-67 was less than 5%. Finally

the lesion was diagnosed with nevus of Ota concurrent with common blue nevus. Therefore

for cases of the nevus of Ota with poor response to laser treatment

the possible coexisting diseases should be suspected.

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Keywords

references

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