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Genetic Evidence for Causal Association Between Hypertension and Chronic Pain: A Bidirectional Two-Sample Mendelian Randomization Study
- Affiliations：
Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
E-mail: garypumch@163.com
- Funds：
DOI：10.24920/004380
CLC：Published：30 September 2024，
Published Online：03 September 2024，
Received：22 May 2024，
Accepted：2024-07-11
- Accepted：
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王帅磊,陈唯韫,刘子嘉等.高血压与慢性疼痛因果关联的遗传证据：一项双向两样本孟德尔随机化研究[J]. 中国医学科学杂志（英文）,2024,39(03):155-161.
Wang Shuai-Lei,Chen Wei-Yun,Liu Zi-Jia,et al.Genetic Evidence for Causal Association Between Hypertension and Chronic Pain: A Bidirectional Two-Sample Mendelian Randomization Study[J].Chinese Medical Sciences Journal,2024,39(03):155-161.
王帅磊,陈唯韫,刘子嘉等.高血压与慢性疼痛因果关联的遗传证据：一项双向两样本孟德尔随机化研究[J]. 中国医学科学杂志（英文）,2024,39(03):155-161. DOI： 10.24920/004380.
Wang Shuai-Lei,Chen Wei-Yun,Liu Zi-Jia,et al.Genetic Evidence for Causal Association Between Hypertension and Chronic Pain: A Bidirectional Two-Sample Mendelian Randomization Study[J].Chinese Medical Sciences Journal,2024,39(03):155-161. DOI： 10.24920/004380.
摘要
目的
2
高血压与慢性疼痛之间是否具有因果关系，或是否受到其他共同风险因素的影响，在观察性研究中尚未得到充分解决。本研究采用孟德尔随机化（Mendelian randomization， MR）方法来探讨二者间的潜在因果关系。
方法
2
研究数据来源于全基因组关联研究（Genome-Wide Association Study， GWAS）汇总数据集，评估了高血压和多种类型慢性疼痛（包括头痛以及胸部、腹部、关节、背部、四肢和多部位慢性疼痛）之间的因果效应。使用随机效应逆方差加权、MR-Egger、加权中位数和加权众数进行了双向两样本MR分析，并以比值比（odds ratio， OR）进行量化。
结果
2
基因预测的原发性高血压与慢性头痛（
OR
= 1.007，95%
CI
：1.003 - 1.011，
P
= 0.002）和四肢痛（
OR
= 1.219，95%
CI
：1.033 - 1.439，
P
= 0.019）风险增加相关。在反向MR分析中，未发现慢性疼痛与原发性高血压之间存在潜在因果关联（
P
>
0.05）。此外，未发现继发性高血压与慢性疼痛之间存在潜在因果关系（
P
>
0.05）。
结论
2
本研究提供了原发性高血压与慢性头痛和四肢痛风险增加之间存在单向因果关系的遗传证据，且未发现继发性高血压与慢性疼痛之间存在因果关系。这些发现为未来在高血压和慢性疼痛管理方面的研究提供了重要的理论依据。
Abstract
Objective
2
The extent to which the association between hypertension and chronic pain in observational studies is either causally linked or influenced by other shared risk factors has not been substantially addressed. In the present study
Mendelian randomization (MR) was employed to examine the potential causal relationship between hypertension and risk of chronic pain.
Methods
2
The study data were derived from the pooled dataset of the genome-wide association study (GWAS)
enabling the evaluation of the causal effects of hypertension on various types of chronic pain including chronic headache as well as chest
abdominal
joint
back
limb
and multisite chronic pain. We performed a bidirectional two-sample MR analysis using random effect inverse variance weighting (IVW)
MR-Egger
weighted median
and weighted mode
quantified by odds ratio (OR).
Results
2
Genetically predicted essent
ial hypertension was associated with an increased risk of chronic headache (
OR
= 1.007
95%
CI
: 1.003‒1.011
P
= 0.002) and limb pain (
OR
= 1.219
95%
CI
: 1.033‒1.439
P
= 0.019). No potential causal associations were identified between chronic pain and essential hypertension in the reverse direction MR (
P
>
0.05). In addition
there was no potential causal association between secondary hypertension and chronic pain (
P
>
0.05).
Conclusion
2
This study provided genetic evidence that a unidirectional causal relationship exists between essential hypertension and the increased risks of chronic headache and limb pain
and no causal relationship was found between secondary hypertension and chronic pain. These findings offer theoretical underpinnings for future research on managing hypertension and chronic pain.
关键词
高血压慢性疼痛孟德尔随机化健康头痛
Keywords
hypertensionchronic painMendelian randomizationhealthchronic headachegenetic evidencelimb pain
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