Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy

Li Yan-feng; Ge Fang-fang; Zhang Yong; You Hui; Zhang Zhen-xin

Your Location：

Home >

Browse articles >

Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy

Chinese Medical Sciences Journal Vol. 30, Issue 3, Pages: 170-173(2015)

Orginal Article | Updated：2024-04-10

- Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy
- Affiliations：
  
  1Department of Neurology,
  2Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
- Funds：
- DOI：
  CLC：
- Published Online：20 June 2015，
  
  Published：2015-06
- Accepted：
Scan QR Code
Li Yan-feng, Ge Fang-fang, Zhang Yong, et al. Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy[J]. Chinese medical sciences journal, 2015, 30(3): 170-173.
DOI：

Li Yan-feng, Ge Fang-fang, Zhang Yong, et al. Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy[J]. Chinese medical sciences journal, 2015, 30(3): 170-173. DOI：

摘要

Abstract

Objective

To study the changes of biomarkers in cerebrospinal fluid (CSF) in cerebral amyloid angiopathy (CAA) dementia and Alzheimer

’

s disease.

Methods

Levels of amyloid protein β (Aβ

Aβ

) and phosphorylated Tau-protein (P-tau) in CSF and ratio of Aβ

/Aβ

were tested in 5 cases with CAA dementia and 20 cases with Alzheimer’s disease collected at Peking Union Medical College Hospital from December 2001 to March 2011.

Results

The levels of Aβ

Aβ

and P-tau in CSF and ratio of Aβ

/Aβ

were (660.4±265.2) ng/L

(7111.0±1033.4) ng/L

(71.8±51.5) ng/L

and 0.077±0.033

respectively in CAA dementia and (663.6±365.6) ng/L

(5115.0±2931.1) ng/L

(47.7±38.8) ng/L

and 0.192±0.140

respectively in Alzheimer’s disease patients. There were no statistically significant differences between CAA dementia and Alzheimer’s disease in terms of these CSF biomarkers (all

0.05).

Conclusion

Measurements of CSF biomarkers may not be helpful in differential diagnosis of CAA and Alzheimer’s disease.

关键词

Keywords

references

Yamada M. Cerebral amyloid angiopathy: emerging concepts. J Stroke 2015 ; 17 : 17 - 30 .

van Rooden S , van der Grond J , van den Boom R , et al . Descriptive analysis of the Boston criteria applied to a Dutch-type cerebral amyloid angiopathy population. Stroke 2009 ; 40 : 3022 - 7 .

Thanvi B , Robinson T. Sporadic cerebral amyloid angiopathy- an important cause of cerebral haemorrhage in older people. Age Ageing 2006 ; 35 : 565 - 71 .

Chao CP , Kotsenas AL , Broderick DF. Cerebral amyloid angiopathy: CT and MR imaging findings. Radiographics 2006 ; 26 : 1517 - 31 .

Guo F , Zhang ZX , Xu Q , et al. Relationship between apolipoprotein E ε4, ε2 alleles and intrauterine growth. Chin J Neurol 2008 ; 41 : 835 - 9 .

Hirohata M , Yoshita M , Ishida C , et al. Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy. Eur J Neurol 2010 ; 17 : 823 - 9 .

Haacke EM , DelProposto ZS, Chaturvedi S, et al. Imaging cerebral amyloid angiopathy with susceptibility-weighted imaging. AJNR Am J Neuroradiol 2007 ; 28 : 316 - 7 .

Biffi A , Anderson CD , Jagiella JM , et al. APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. Lancet Neurol 2011 ; 10 : 702 - 9 .

Premkumar DR , Cohen DL , Hedera P , et al. Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol 1996 ; 148 : 2083 - 95 .

Verghese PB , Castellano JM , Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol 2011 ; 10 : 241 - 52 .

Viswanathan A , Greenberg SM. Cerebral amyloid angiopathy in the elderly. Annals of Neurology 2011 ; 70 : 871 - 80 .

Verbeek MM , Kremer BP , Rikkert MO , et al. Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy. Ann Neurol 2009 ; 66 : 245 - 9 .

Renard D , Castelnovo G , Wacongne A , et al. Interest of CSF biomarker analysis in possible cerebral amyloid angiopathy cases defined by the modified Boston criteria. J Neurol 2012 ; 259 : 2429 - 33 .

Views

1453

Downloads

CSCD

Alert me when the article has been cited

Submit

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰