Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials

Yang Bo; Wang Jiansheng

Your Location：

Home >

Browse articles >

Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials

Chinese Medical Sciences Journal Vol. 32, Issue 1, Pages: 13-21(2017)

Orginal Article | Updated：2024-04-10

- Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials
- Affiliations：
  
  Department of Urology, Xixi Hospital of Hangzhou, Hangzhou 310023, China
- Author bio：
  
  *Corresponding author Tel: 86-571-86481510; Fax: 86-571-86481510; E-mail: xxyyyangbo@aliyun.com
- Funds：
- DOI：
  CLC：
- Published Online：11 April 2017，
  
  Published：2017-04
- Accepted：
Scan QR Code
Yang Bo, Wang Jiansheng. Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials[J]. Chinese medical sciences journal, 2017, 32(1): 13-21.
DOI：

Yang Bo, Wang Jiansheng. Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials[J]. Chinese medical sciences journal, 2017, 32(1): 13-21. DOI：

摘要

Abstract

Objective

To gain insight on how exercise affects the outcomes of prostate cancer patients treated with androgen deprivation therapy

specifically cancer-related fatigue (CRF) and quality of life (QoL).

Methods

Systematic searches for randomized clinical trials (RCTs) evaluating the effects of exercise on CRF and QoL of prostate cancer patients receiving androgen deprivation therapy were carried out to identify the eligible studies from EMBASE

PubMed and Cochrane library. Related data were extracted from eligible studies and then subjected to Reviewer Manage 5.3 for analysis. Standardized mean differences (SMD) and its 95% confidence interval (

) were calculated.

Results

In all

10 RCTs involving 841 prostate cancer patients (448 of whom exercised and 393 did not) were included in this study. With respect to CRF

there was good consistency among different studies

and it was remarkably reduced in the exercise group (SMD=-0.32

95%

: -0.45 to -0.18

0.00001

=784). In regards to QoL

there was also good consistency among different studies

and it was also improved significantly in the exercise group (SMD=0.21

95%

: 0.08 to 0.34

=0.002

=841).

Conclusion

Exercise both reduced CRF and improved QoL in prostate cancer patients receiving androgen deprivation therapy.

关键词

Keywords

references

Brown JC , Huedo-Medina TB , Pescatello LS , et al. Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2011 ; 20 : 123 - 33 .

Janda M , Gerstner N , Obermair A , et al. Quality of life changes during conformal radiation therapy for prostate carcinoma. Cancer 2000 ; 89 : 1322 - 8 .

Kruijsen-Jaarsma M , Révész D , Bierings MB , et al. Effects of exercise on immune function in patients with cancer: a systematic review. Exerc Immunol Rev 2013 ; 19 : 120 - 43 .

Betof AS , Dewhirst MW , Jones LW. Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain Behav Immun 2013 ; 30 : S75 - 87 .

Courneya KS , Segal RJ , McKenzie DC, et al. Effects of exercise during adjuvant chemotherapy on breast cancer outcomes. Med Sci Sports Exerc 2014 ; 46 : 1744 - 51 .

Victorson D , Barocas J , Song J , et al. Reliability across studies from the functional assessment of cancer therapy-general (FACT-G) and its subscales: a reliability generalization. Qual Life Res 2008 ; 17 : 1137 - 46 .

Baade PD , Youlden DR , Cramb SM , et al. Epidemiology of prostate cancer in the Asia-Pacific region. Prostate Int 2013 ; 1 : 47 - 58 .

Schroeder A , Herrmann A , Cherryholmes G , et al. Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling. Cancer Res 2014 ; 74 : 1227 - 37 .

Alberga AS , Segal RJ , Reid RD , et al. Age and androgen- deprivation therapy on exercise outcomes in men with prostate cancer. Support Care Cancer 2012 ; 20 : 971 - 81 .

Shahinian VB , Kuo Y-F , Freeman JL , et al. Risk of the “androgen deprivation syndrome” in men receiving androgen deprivation for prostate cancer. Arch Intern Med 2006 ; 166 : 465 - 71 .

Culos-Reed SN , Robinson JW , Lau H , et al. Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention. Support Care Cancer 2010 ; 18 : 591 - 9 .

Bourke L , Doll H , Crank H , et al. Lifestyle intervention in men with advanced prostate cancer receiving androgen suppression therapy: a feasibility study. Cancer Epidemiol Biomarkers Prev 2011 ; 20 : 647 - 57 .

Keogh JW , MacLeod RD. Body composition, physical fitness, functional performance, quality of life, and fatigue benefits of exercise for prostate cancer patients: a systematic review. J Pain Symptom Manage 2012 ; 43 : 96 - 110 .

Winters-Stone KM , Beer TM. Review of exercise studies in prostate cancer survivors receiving androgen deprivation therapy calls for an aggressive research agenda to generate high-quality evidence and guidance for exercise as standard of care. J Clin Oncol 2014 ; 32 : 2518 - 9 .

Liberati A , Altman DG , Tetzlaff J , et al. The PRISMA statement for reporting systematic reviews and meta- analyses of studies that evaluate health care interven- tions: explanation and elaboration. Ann Intern Med 2009 ; 151 : W65 - 94 .

16.Higgins J , Green S . Cochrane handbook for systematic reviews of interventions Version 5.1.0 [updated March 2011 ]. The Cochrane Collaboration. Available from: www.cochrane-handbook.org www.cochrane-handbook.org

Higgins JP , Thompson SG , Deeks JJ , et al. Measuring inconsistency in meta-analyses. BMJ 2003 ; 327 : 557 - 60 .

Bourke L , Gilbert S , Hooper R , et al. Lifestyle changes for improving disease-specific quality of life in sedentary men on long-term androgen-deprivation therapy for advanced prostate cancer: a randomised controlled trial. Eur Urol 2014 ; 65 : 865 - 72 .

Buffart LM , Galvão DA , Mai JC , et al. Mediators of the resistance and aerobic exercise intervention effect on physical and general health in men undergoing androgen deprivation therapy for prostate cancer. Cancer 2014 ; 120 : 294 - 301 .

Cormie P , Galvão DA , Spry N , et al. Can supervised exercise prevent treatment toxicity in prostate cancer patients initiating androgen deprivation therapy: a randomised controlled trial. BJU International 2014 ; 115 : 256 - 66 .

Galvão DA , Taaffe DR , Spry N , et al. Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial. J Clin Oncol 2010 ; 28 : 340 - 7 .

O’Neill RF , Haseen F , Murray LJ . A randomised controlled trial to evaluate the efficacy of a 6-month dietary and physical activity intervention for patients receiving androgen deprivation therapy for prostate cancer. J Cancer Surviv 2015 ; 9 : 431 - 40 .

Segal RJ , Reid RD , Courneya KS , et al. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol 2003 ; 21 : 1653 - 9 .

Segal RJ , Reid RD , Courneya KS , et al. Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. J Clin Oncol 2009 ; 27 : 344 - 51 .

Nilsen TS , Raastad T , Skovlund E , et al. Effects of strength training on body composition, physical functioning, and quality of life in prostate cancer patients during androgen deprivation therapy. Acta Oncologica 2015 ; 54 : 1 - 9 .

Floyd A , Moyer A. Group versus individual exercise interventions for women with breast cancer: a meta- analysis. Health Psychol Rev 2010 ; 4 : 22 - 41 .

Sherrington C , Whitney JC , Lord SR , et al. Effective exercise for the prevention of falls: a systematic review and meta-analysis. J Am Geriatr Soc 2008 ; 56 : 2234 - 43 .

Gardner JR , Livingston PM , Fraser SF. Effects of exercise on treatment-related adverse effects for patients with prostate cancer receiving androgen-deprivation therapy: a systematic review. J Clin Oncol 2014 ; 32 : 335 - 46 .

Views

5080

Downloads

CSCD

Alert me when the article has been cited

Submit

Publicity Resources

Transarterial Embolization versus Translumber Embolization for Type Ⅱ Endoleak after Endovascular Abdominal Aortic Aneurysm Repair: A Meta-Analysis

Efficacy of Short-term Dual Antiplatelet Therapy after Implantation of Second-generation Drug-eluting Stents: A Meta-analysis and Systematic Review

Meta-analysis of aspirin-heparin therapy for un-explained recurrent miscarriage

Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis

Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndrome: a Meta-analysis

Related Author

Zheng Yuehong

Wang Wei

Chen Mengyin

Ji Lei

Zhang Xu

Huang Peisen

Yu Yuan

Han Xikun

Related Institution

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College

State Key Laboratory of Cardiovascular Disease

National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College

Department of Gynaecology and Obstetrics, XiXi Hospital of Hangzhou

Department of Gynaecology and Obstetrics, Hangzhou Red Cross Hospital

⁰