Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndrome: a Meta-analysis

Qiu Lei; Liu Jing; Hei Qi-ming

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Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndrome: a Meta-analysis

Chinese Medical Sciences Journal Vol. 30, Issue 1, Pages: 44-50(2015)

Orginal Article | Updated：2024-04-10

- Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndrome: a Meta-analysis
- Affiliations：
  
  1. 1Department of Health Management, School of Management, Hainan Medical University, Haikou 570100, China
  2. 2Department of Labor and Social Security, School of Management, Hainan Medical University, Haikou 570100, China
- Author bio：
  
  *Corresponding author Tel: 86-898-66891279, E-mail:1005727838@qq.com
- Funds：
- DOI：
  CLC：
- Received：05 July 2014，
  
  Published Online：20 February 2015，
  
  Published：2015-02
- Accepted：
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Qiu Lei, Liu Jing, Hei Qi-ming. Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndrome: a Meta-analysis[J]. Chinese medical sciences journal, 2015, 30(1): 44-50.
DOI：

Qiu Lei, Liu Jing, Hei Qi-ming. Association between Two Polymorphisms of Follicle Stimulating Hormone Receptor Gene and Susceptibility to Polycystic Ovary Syndrome: a Meta-analysis[J]. Chinese medical sciences journal, 2015, 30(1): 44-50. DOI：

摘要

Abstract

Objective

To investigate the association between two polymorphisms of follicle stimulating hormone receptor (FSHR) gene and polycystic ovary syndrome (PCOS) susceptibility.

Methods

Case-control studies on relationship of Thr307Ala and Asn680Ser polymorphisms in FSHR gene and PCOS susceptibility were searched from PubMed

ISI web of knowledge

EBSCO

and China National Knowledge Infrastructure (CNKI) databases up to March 21

2013. The pooled odds ratio (

) and 95% confidence interval (

) were calculated using fixed- or random-effect model based on heterogeneity test in 5 genotype models analyses.

Results

A total of 11 studies were included in the Meta-analysis. The random-effect analysis showed Asn680Ser was significantly associated with the reduced susceptibility to PCOS with dominant model (Asn/Asn+Asn/Ser

. Ser/Ser

=0.83

95%

: 0.69-1.00)

recessive model (Asn/Asn

. Asn/Ser+ Ser/Ser

=0.84

95%

: 0.72-0.98)

homozygote comparison (Asn/Asn

. Ser/Ser

=0.79

95%

: 0.63-0.98)

and the allele contrast (Asn

. Ser

=0.87

95%

: 0.79-0.97) respectively(

=0.02

=56.0%)

being protective factors for PCOS. However

no significant associations were found between Thr307Ala and PCOS.

Conclusion

There might be a significant association between Asn680Ser polymorphism and PCOS.

关键词

Keywords

references

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