BRAF V600E Mutation as a Predictive Factor of Anti-EGFR Monoclonal Antibodies Therapeutic Effects in Metastatic Colorectal Cancer: a Meta-analysis

Qi Wang; Wei-guo Hu; Qi-bin Song; Jia Wei

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BRAF V600E Mutation as a Predictive Factor of Anti-EGFR Monoclonal Antibodies Therapeutic Effects in Metastatic Colorectal Cancer: a Meta-analysis

Chinese Medical Sciences Journal Issue 4, Pages: 197-203(2014)

Updated：2024-04-10

- BRAF V600E Mutation as a Predictive Factor of Anti-EGFR Monoclonal Antibodies Therapeutic Effects in Metastatic Colorectal Cancer: a Meta-analysis
- Affiliations：
  
  Department of Oncology, Renmin Hospital of Wuhan University,Wuhan,China,430060
- Author bio：
- Funds：
- DOI：
  CLC：
- Published Online：28 November 2014，
  
  Published：2014
- Accepted：
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Qi Wang, Wei-guo Hu, Qi-bin Song, et al. BRAF V600E Mutation as a Predictive Factor of Anti-EGFR Monoclonal Antibodies Therapeutic Effects in Metastatic Colorectal Cancer: a Meta-analysis[J]. Chinese medical sciences journal, 2014, (4): 197-203.
DOI：

Qi Wang, Wei-guo Hu, Qi-bin Song, et al. BRAF V600E Mutation as a Predictive Factor of Anti-EGFR Monoclonal Antibodies Therapeutic Effects in Metastatic Colorectal Cancer: a Meta-analysis[J]. Chinese medical sciences journal, 2014, (4): 197-203. DOI：

摘要

Objective To investigate the correlation between BRAF V600E mutation and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) therapeutic effects in metastatic colorectal cancer. Methods Studies were included into meta-analysis to investigate the association between BRAF V600E mutation and clinical outcome in metastatic colorectal cancer patients treated with anti-EGFR MoAbs. Results A total of 7 studies were included in this meta-analysis. The 7 studies included 1352 patients in total

sample sizes ranged from 67 to 493. Objective response rate (ORR)

progression-free survival (PFS) and overall survival (OS) were collected from included studies and were used to assess the strength of the relation. In patients with wild-type KRAS

the pooled odds ratio for ORR of mutant BRAF over wild-type BRAF was 0.27 (95% CI=0.10-0.70). BRAF mutation predicted a deterioration in PFS and OS in wild-type KRAS patients treated with anti-EGFR MoAbs (hazard ratio=2.78

95% CI=1.62-4.76; hazard ratio=2.54

95% CI=1.93-3.32). Conclusion BRAF V600E mutation is related to lack of response and worse survival in wild-type KRAS metastatic colorectal cancer patients treated with anti-EGFR MoAbs.

Abstract

sample sizes ranged from 67 to 493. Objective response rate (ORR)

progression-free survival (PFS) and overall survival (OS) were collected from included studies and were used to assess the strength of the relation. In patients with wild-type KRAS

95% CI=1.62-4.76; hazard ratio=2.54

95% CI=1.93-3.32). Conclusion BRAF V600E mutation is related to lack of response and worse survival in wild-type KRAS metastatic colorectal cancer patients treated with anti-EGFR MoAbs.

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