Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

Yu Yong-qiang; Yang Huai-an; Xiao Ming; Wang Jing-wei; Huang Dong-yan; Bhambhani Yagesh; Sonnenberg Lyn; Clark Brenda; Jin Yuan-zhe; Fu Wei-neng; Zhang Jie; Yu Qian; Liang Xue-ting; Zhang Ming

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Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

Chinese Medical Sciences Journal Vol. 30, Issue 3, Pages: 179-188(2015)

Orginal Article | Updated：2024-04-10

- Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss
- Affiliations：
  
  1Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, Edmonton, AB T6G 2B7, Canada
  12Department of Surgery-Otolaryngology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2B7, Canada
  4Department of Obstetrics and Gynecology, Edmonton, AB T6G 2B7, Canada
  2Department of Otolaryngology, The First Affiliated Hospital, Shenyang 110001, China
  8Department of Medical Genetics, Shenyang 110001, China
  9Department of Biochemistry, China Medical University, Shenyang 110001, China
  11Department of Medical Imageology, China Medical University, Shenyang 110001, China
  3Department of Surgery, The People’s Hospital of Liaoning Province, Shenyang 110016, China;
  5Department of Otolaryngology-Head & Neck Surgery, PLA General Hospital, Beijing 100853, China;
  6Department of Developmental Pediatrics
  13Department of Audiology, Glenrose Rehabilitation Hospital, Edmonton, AB T5G 0B7, Canada
  7Department of Cardiology, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China
  10 School of Business, University of Alberta, Edmonton, AB T6G 2G4, Canada
- Author bio：
- Funds：
- DOI：
  CLC：
- Published Online：20 June 2015，
  
  Published：2015-06
- Accepted：
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Yu Yong-qiang, Yang Huai-an, Xiao Ming, et al. Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss[J]. Chinese medical sciences journal, 2015, 30(3): 179-188.
DOI：

Yu Yong-qiang, Yang Huai-an, Xiao Ming, et al. Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss[J]. Chinese medical sciences journal, 2015, 30(3): 179-188. DOI：

摘要

Abstract

In this article

the mechanism of inheritance behind inherited hearing loss and genetic susceptibility in noise-induced hearing loss are reviewed. Conventional treatments for sensorineural hearing loss (SNHL)

i.e. hearing aid and cochlear implant

are effective for some cases

but not without limitations. For example

they provide little benefit for patients of profound SNHL or neural hearing loss

especially when the hearing loss is in poor dynamic range and with low frequency resolution. We emphasize the most recent evidence-based treatment in this field

which includes gene therapy and allotransplantation of stem cells. Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss. Although some treatments are still at the experimental stage

it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application.

关键词

Keywords

references

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