Features of Computed Tomography Perfusion of Mediastinal Lymphadenopathies: a Pathology-based Retrospective Study

Ou-yang Lin; Lu Guang-ming

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Features of Computed Tomography Perfusion of Mediastinal Lymphadenopathies: a Pathology-based Retrospective Study

Chinese Medical Sciences Journal Vol. 30, Issue 3, Pages: 162-169(2015)

Orginal Article | Updated：2024-04-10

- Features of Computed Tomography Perfusion of Mediastinal Lymphadenopathies: a Pathology-based Retrospective Study
- Affiliations：
  
  1. 1thDepartment of Radiology, The PLA 175th Hospital & Affiliated Southeast Hospital of Xiamen University, Fujian 363000, China
  2. 2Department of Radiology, Nanjing General Hospital of Nanjing Military Command, Nanjing 200012, China
- Author bio：
  
  *Corresponding author Tel: 86-25-80860185, E-mail: cjr.luguangming@vip.163.com
- Funds：
- DOI：
  CLC：
- Published Online：20 June 2015，
  
  Published：2015-06
- Accepted：
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Ou-yang Lin, Lu Guang-ming. Features of Computed Tomography Perfusion of Mediastinal Lymphadenopathies: a Pathology-based Retrospective Study[J]. Chinese medical sciences journal, 2015, 30(3): 162-169.
DOI：

Ou-yang Lin, Lu Guang-ming. Features of Computed Tomography Perfusion of Mediastinal Lymphadenopathies: a Pathology-based Retrospective Study[J]. Chinese medical sciences journal, 2015, 30(3): 162-169. DOI：

摘要

Abstract

Objective

To explore the features of various mediastinal lymphadenopathies using computed tomography perfusion (CTP).

Methods

CTP parameters (CTPs) of the selected mediastinal nodes from 59 patients with pathology-proven malignant lymph nodes and of those from 29 patients with clinically diagnosed or pathology-proven inflammatory lymphadenopathies were collected. Patients were divided into subgroups by etiology and phase of primary disease

including different pathological malignant nodes and diverse inflammatory nodes. CTPs were defined as blood flow (BF)

blood volume (BV)

mean transit time (MTT)

permeability (PMB)

and time to peak (TTP). Differences of CTPs were compared between malignant and benign nodes

and among subgroups

respectively.

Results

In the mediastinum

no significant differences of CTPs were found between malignant and benign groups (all

0.05)

the same for subgroups of malignant nodes (all

0.05). Acute lymphadenitis had higher BF and BV than chronic inflammatory

lymphoid tuberculosis

sarcoidosis and malignant nodes. The BF of malignant nodes was markedly slower than that of acute lymphadenitis (

=0.01)

but faster than chronic inflammatory nodes (

=0.04) and sarcoidosis (

=0.03)

with no significant difference compared with lymphoid tuberculosis. Pneumonia-complicated lymphoid tuberculosis showed the longest MTT while sarcoidosis displayed the shortest MTT

and inflammatory nodes

lymphoid tuberculosis without complicated pneumonia and malignant nodes had moderate MTT.

Conclusion

CTPs show promising potential in distinguishing various lymphadenopathies in the mediastinum

but more studies are needed to improve their specificity.

关键词

Keywords

references

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