Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis

Guo Chun-lan; Zhao* Ji-zhi; Zhang Jie; Dong Hai-tao

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Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis

Chinese Medical Sciences Journal Vol. 30, Issue 4, Pages: 210-217(2015)

Orginal Article | Updated：2024-04-10

- Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis
- Affiliations：
  
  Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：2015-08
- Accepted：
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Guo Chun-lan, Zhao* Ji-zhi, Zhang Jie, et al. Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis[J]. Chinese medical sciences journal, 2015, 30(4): 210-217.
DOI：

Guo Chun-lan, Zhao* Ji-zhi, Zhang Jie, et al. Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis[J]. Chinese medical sciences journal, 2015, 30(4): 210-217. DOI：

摘要

Abstract

Objective

To assess the efficacy and safety of topical tacrolimus for erosive oral lichen planus (EOLP).

Methods

Literatures published up to December 2013 were searched from PubMed

Embase

CENTRAL

Chinese BioMedical Literature Database (CBM)

and System for Information on Grey Literature in Europe (SIGLE). All randomized controlled trials (RCTs) of topical tacrolimus for EOLP which compared with other interventions or a placebo were considered in this Meta-analysis. Two researchers collected data independently. The assessment of methodological quality was based on Cochrane Handbook and the materials were analyzed with the software Revman 5.2.5. The primary outcome measures were the symptoms (e.g. pain

discomfort) complained by patients. The secondary outcome measures included the improvement rate of clinical signs assessed by the investigators and the incidence of adverse effects (e.g. clinical candidiasis).

Results

A total of 9 RCTs involving 476 patients were finally included. The pooled odds ratio (

) of clinical improvement for topical tacrolimus

. topical corticosteroids was 1.19 [95% confidence interval (

): 0.64-2.22

: 44%]. Regarding to 0.1% tacrolimus and 0.03% tacrolimus

the pooled

were 1.87 (95 %

: 0.60-5.82) and 1.47 (95 %

: 0.14-16.04) respectively in subgroup analysis. No serious adverse events were reported in topical tacrolimus group.

Conclusions

There was no evidence to support that topical tacrolimus for EOLP was more effective and safer than topical corticosteroids in this Meta-analysis. Clinical assessment criteria should be established and accepted by clinicians and researchers before further RCTs are undertaken.

关键词

Keywords

references

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