Physiological Testosterone Retards Cardiomyocyte Aging in Tfm Mice via Androgen Receptor-independent Pathway<sup>025B3;</sup>

Li Zhang; Da Lei; Gui-ping Zhu; Lei Hong; Sai-zhu Wu

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Physiological Testosterone Retards Cardiomyocyte Aging in Tfm Mice via Androgen Receptor-independent Pathway^025B3;

null Issue 2, Pages: 88-94(2013)

Updated：2024-04-10

- Physiological Testosterone Retards Cardiomyocyte Aging in Tfm Mice via Androgen Receptor-independent Pathway^025B3;
- Affiliations：
  
  1. Department of Cardiology, First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou,China,510080
  2. Department of Cardiology, Nanfang Hospital, Southern Medical University,Guangzhou,China,510515
- Author bio：
- Funds：
- DOI：
  CLC：
- Published Online：26 June 2013，
  
  Published：2013
- Accepted：
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Li Zhang, Da Lei, Gui-ping Zhu, et al. Physiological Testosterone Retards Cardiomyocyte Aging in Tfm Mice via Androgen Receptor-independent Pathway^025B3;[J]. Null, 2013, (2): 88-94.
DOI：

Li Zhang, Da Lei, Gui-ping Zhu, et al. Physiological Testosterone Retards Cardiomyocyte Aging in Tfm Mice via Androgen Receptor-independent Pathway^025B3;[J]. Null, 2013, (2): 88-94. DOI：

摘要

Male littermates and testicular feminized (Tfm) mice were randomly separated into 4 experimental groups littermate controls (n=8)

Tfm mice (n=7)

testosterone-treated Tfm mice (n=8)

and Tfm mice treated with testosterone in combination with the aromatase inhibitor anastrazole (n=7). Cardiomyocytes were isolated from mouse left ventricles

the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)

and the amount of malondialdehyde (MDA) were measured using colorimetry method

and expression of p16

INK4α

and retinoblastoma (Rb) proteins were detected by Western blotting.

Abstract

Male littermates and testicular feminized (Tfm) mice were randomly separated into 4 experimental groups littermate controls (n=8)

Tfm mice (n=7)

testosterone-treated Tfm mice (n=8)

and Tfm mice treated with testosterone in combination with the aromatase inhibitor anastrazole (n=7). Cardiomyocytes were isolated from mouse left ventricles

the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)

and the amount of malondialdehyde (MDA) were measured using colorimetry method

and expression of p16

INK4α

and retinoblastoma (Rb) proteins were detected by Western blotting.

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Physiological Testosterone Retards Cardiomyocyte Aging in Tfm Mice via Androgen Receptor-independent Pathway025B3;

DOI：

摘要

Abstract

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Physiological Testosterone Retards Cardiomyocyte Aging in Tfm Mice via Androgen Receptor-independent Pathway^025B3;