Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes

public health decision making

and primary prevention synthesis. Lead is one of the neurotoxicants that seems to be involved in the etiology of psychologies. Biomarkers are generally classified into three groups: biomarkers of exposure

effect

and susceptibility.The main body compartments that store lead are the blood

soft tissues

and bone; the half-life of lead in these tissues is measured in weeks for blood

months for soft tissues

and years for bone. Within the brain

lead-induced damage in the prefrontal cerebral cortex

hippocampus

and cerebellum can lead to a variety of neurological disorders

such as brain damage

mental retardation

behavioral problems

nerve damage

and possibly Alzheimers disease

Parkinson ’s disease

and schizophrenia. This paper presents an overview of biomarkers of lead exposure and discusses the neurotoxic effects of lead with regard to children and adults.