Expression of Plasminogen Activator Inhibitor-2 is Negatively Associated with Invasive Potential in Hepatocellular Carcinoma Cells△

Ye Jin; Li Zhou; Ke-min Jin; and Bao-cai Xing

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Expression of Plasminogen Activator Inhibitor-2 is Negatively Associated with Invasive Potential in Hepatocellular Carcinoma Cells△

null Issue 1, Pages: 16-19(2013)

Updated：2024-04-10

- Expression of Plasminogen Activator Inhibitor-2 is Negatively Associated with Invasive Potential in Hepatocellular Carcinoma Cells△
- Affiliations：
  
  1. Clinical Research Laboratory
  2. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China,100730
  3. ,China
  4. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Hepatobiliary Surgery I, Peking University Cancer Hospital,Beijing,China,100142
- Author bio：
- Funds：
- DOI：
  CLC：
- Published Online：26 March 2013，
  
  Published：2013
- Accepted：
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Ye Jin, Li Zhou, Ke-min Jin, et al. Expression of Plasminogen Activator Inhibitor-2 is Negatively Associated with Invasive Potential in Hepatocellular Carcinoma Cells△[J]. Null, 2013, (1): 16-19.
DOI：

Ye Jin, Li Zhou, Ke-min Jin, et al. Expression of Plasminogen Activator Inhibitor-2 is Negatively Associated with Invasive Potential in Hepatocellular Carcinoma Cells△[J]. Null, 2013, (1): 16-19. DOI：

摘要

To investigate the association between plasminogen activator inhibitor (PAI)-2 expression and invasive potential in hepatocellular carcinoma (HCC) cells. Methods The HCC cell lines with high

low

and non-metastatic potentials

namely MHCC97-H

MHCC97-L

and SMMC-7721 respectively

were cultured in vitro. Matrigel invasion assay and Western blot of PAI-2 protein expression were conducted. Results The number of invaded cells in MHCC97-L was significantly higher than that in SMMC-7721 (P=0.005)

whereas that in MHCC97-H was higher than in MHCC97-L (P=0.017) and SMMC-7721 (P=0.001). Contrarily

PAI-2 protein expression was gradually reducing from SMMC-7721

MHCC97-L

to MHCC97-H (MHCC97-H vs. MHCC97-L

P<0.001; MHCC97-H vs. SMMC-7721

P=0.001; MHCC97-L vs. SMMC-7721

P=0.001). The Pearson’s correlation analysis revealed a significant negative association between invaded cell number and PAI-2 expression (r=-0.892

P=0.001). Conclusion PAI-2 expression may be negatively associated with the invasive potential of HCC.

Abstract

To investigate the association between plasminogen activator inhibitor (PAI)-2 expression and invasive potential in hepatocellular carcinoma (HCC) cells. Methods The HCC cell lines with high

low

and non-metastatic potentials

namely MHCC97-H

MHCC97-L

and SMMC-7721 respectively

whereas that in MHCC97-H was higher than in MHCC97-L (P=0.017) and SMMC-7721 (P=0.001). Contrarily

PAI-2 protein expression was gradually reducing from SMMC-7721

MHCC97-L

to MHCC97-H (MHCC97-H vs. MHCC97-L

P<0.001; MHCC97-H vs. SMMC-7721

P=0.001; MHCC97-L vs. SMMC-7721

P=0.001). The Pearson’s correlation analysis revealed a significant negative association between invaded cell number and PAI-2 expression (r=-0.892

P=0.001). Conclusion PAI-2 expression may be negatively associated with the invasive potential of HCC.

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