Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△

Bao-zhi Fang; Guang-sheng He; Hai-xia Zhou; Hui-rong Chang; De-pei Wu; Ai-ning Sun; and Su-ning Chen

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Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△

null Issue 1, Pages: 58-60(2013)

Updated：2024-04-10

- Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△
- Affiliations：
  
  1. Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University,Suzhou,China,215006
  2. ,China
  3. The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital),Suzhou,China,215002
- Author bio：
- Funds：
- DOI：
  CLC：
- Published Online：26 March 2013，
  
  Published：2013
- Accepted：
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Bao-zhi Fang, Guang-sheng He, Hai-xia Zhou, et al. Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△[J]. Null, 2013, (1): 58-60.
DOI：

Bao-zhi Fang, Guang-sheng He, Hai-xia Zhou, et al. Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△[J]. Null, 2013, (1): 58-60. DOI：

摘要

APLASTIC anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes

resulting in the apoptosis of hematopoietic cells and bone marrow failure.

Currently

hematopoietic stem cell transplantation (HSCT)

immunosuppressive - therapy (IST)

and supportive care (e.g. transfusion adjuvant therapy

hematopoietic growth factors

and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST.

This article reported a severe AA patient who failed to respond to IST

but achieved spontaneous remission three times after granulocyte transfusions from related donors. Such cases have rarely been reported. Existence of human leukocyte antigen (HLA) cross between the patient and his relatives may influence the T cell-mediated immunity

which might explain this patient’s recovery.

Abstract

APLASTIC anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes

resulting in the apoptosis of hematopoietic cells and bone marrow failure.

Currently

hematopoietic stem cell transplantation (HSCT)

immunosuppressive - therapy (IST)

and supportive care (e.g. transfusion adjuvant therapy

hematopoietic growth factors

and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST.

This article reported a severe AA patient who failed to respond to IST

which might explain this patient’s recovery.

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RELATIONSHIP BETWEEN HUMAN PARVOVIRUS B19 INFECTION AND APLASTIC ANEMIA

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