Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy

Liu-mei Hu; Xia Lei; Bo Ma; Yu Zhang; Yan Yan; Ya-lanWu; Ge-zhi Xu; Wen Ye; Ling Wang; Guo-xu Xu; Guo-tong Xu; Wei-ye Li

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Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy

Chinese Medical Sciences Journal Issue 2, Pages: 69-76(2011)

Updated：2024-04-10

- Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy
- Affiliations：
  
  1. Department of Ophthalmology,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences& Peking Union Medical College,Beijing,China,100730
  2. Tongji Eye Instituteand Department of Regenerative Medicine, Tongji University School of Medicine,Shanghai,China,200092
  3. Laboratory of Clinical Visual Sciences, Institute ofHealth Sciences, Shanghai Institutes for Biological Sciences, Chinese Academyof Sciences & Shanghai Jiao Tong University School of Medicine,Shanghai,China,200025
  4. Department of Ophthalmology, Eye and ENT Hospital, FudanUniversity,Shanghai,China,200031
  5. Department of Ophthalmology,Huashan Hospital Affiliated toFudan University,Shanghai,China,200040
  6. Department ofOphthalmology,Ruijin HospitalAffiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China,200025
  7. Department of Ophthalmology, Second Affiliated Hospital of Soochow University,Jiangsu,Suzhou,China,215004
  8. Department of Ophthalmology, Drexel University College of Medicine, Philadelphia,PA,USA,19107
- Author bio：
- Funds：
- DOI：
  CLC：
- Published Online：24 June 2011，
  
  Published：2011
- Accepted：
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Liu-mei Hu, Xia Lei, Bo Ma, et al. Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy[J]. Chinese medical sciences journal, 2011, (2): 69-76.
DOI：

Liu-mei Hu, Xia Lei, Bo Ma, et al. Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy[J]. Chinese medical sciences journal, 2011, (2): 69-76. DOI：

摘要

Objective To investigate the possible involvement of erythr opoietin (EPO)/erythropoietin receptor (EPOR) system in neovascularization and vascular regeneration in diabetic retinopathy (DR). Methods EPOR positive circulating progenitor cells (CPCs: CD34

) and endothelial progenitor cells (EPCs: CD34

KDR

) were assessed by flow cytometry in type 2 diabetic patients with different stages of DR. The cohort consisted of age- and sex-matched control patients with out diabetes ( n=7)

non-proliferative DR (NPDR

n=7)

non-proliferative DR (PDR

n=8)

and PDR complicated with diabetic nephr opathy (PDR-DN

n=7).Results The numbers of EPOR

CPCs and EPOR

EPCs were reduced remarkably in NPDR compared with the control group (both P＜0.01)

whereas rebounded in PDR and PDR-DN groups in varyingdegrees. Similar changes were observed in respect of the proportion of EPOR

CPCs in CPCs (NPDR vs. control

P＜0.01) and that of EPOR

EPCs in EPCs (NPDR vs. control

P＜0.05).Conclusion Exogenous EPO

mediated via the EPO/EPOR system of EPCs

may alleviate the impaired vascular regeneration in NPDR

whereas it might aggravate retinal neovascularization in PDR due to a rebound of EPOR

EPCs associated with ischemia.

Abstract

) and endothelial progenitor cells (EPCs: CD34

KDR

) were assessed by flow cytometry in type 2 diabetic patients with different stages of DR. The cohort consisted of age- and sex-matched control patients with out diabetes ( n=7)

non-proliferative DR (NPDR

n=7)

non-proliferative DR (PDR

n=8)

and PDR complicated with diabetic nephr opathy (PDR-DN

n=7).Results The numbers of EPOR

CPCs and EPOR

EPCs were reduced remarkably in NPDR compared with the control group (both P＜0.01)

whereas rebounded in PDR and PDR-DN groups in varyingdegrees. Similar changes were observed in respect of the proportion of EPOR

CPCs in CPCs (NPDR vs. control

P＜0.01) and that of EPOR

EPCs in EPCs (NPDR vs. control

P＜0.05).Conclusion Exogenous EPO

mediated via the EPO/EPOR system of EPCs

may alleviate the impaired vascular regeneration in NPDR

whereas it might aggravate retinal neovascularization in PDR due to a rebound of EPOR

EPCs associated with ischemia.

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