ULCERATIVE colitis is a chronic inflammatory disease characterized by diffuse mucosal inflammation involving the rectum and extending proximally to involve all or part of the colon. A step-up approach for medical therapy is routinely applied

from 5-aminosalicylic acid (ASA) compounds

corticosteroids

immunomodulators

and biologics.1 Thrombosis

mainly venous

is a rare and well-recognized extra-intestinal manifestation of inflammatory bowel disease.2 In this article

we report the use of thrombolytic and antithrombotic therapy for the venous thrombosis in a 55-year-old male patient with refractory and active ulcerative colitis with excellent outcome.